IADR Abstract Archives
Ozone Treatment of Recurrent Aphthous Stomatitis
Objectives: This study evaluated the effects of ozone to treat recurrent aphthous stomatitis (RAS); especially its effects on size and duration of ulcers and pain levels experienced by participants.
Methods: After randomization, sixty nine participants (30 men and 39 women, mean age ± SD: 27.2 ±7.5 years) with RAS were recruited into a test group (group 1) and a control group of 69 RAS patients were also recruited. RAS lesions in group one were exposed to ozone from the healOzone® X4 machine (Curozone, Germany) for 60 seconds while participants in the control group received only air from the same unit through special disposable silicone cups. Ulcer size was recorded for each participant at baseline and daily for 15 days. Pain was assessed with a VAS score from 0 to 10 at study baseline and daily for 15 days. Ulcers duration was determined by recording the time they required to disappear.
Results: No significant relationships were found between age and gender and each of ulcer duration, ulcer size, and pain levels (p>0.05) in both groups except that males had lower ulcer duration than females (p=0.020) in the control group. Ulcer size was significantly reduced starting from the second day in group one and fourth day in controls (p≤0.004). Also, pain levels were significantly reduced starting from the first day in group one and the third day in controls (p≤0.001). Ulcer duration, ulcer size after day 2, pain levels at baseline after ozone application and pain levels from day 1 to 10 were more reduced in group one treated with ozone in comparison to controls.
Conclusions: Application of ozone from the healOzone on RAS lesions for 60 seconds led to a reduction of pain levels as well as enhanced healing of the ulcers by reducing the size and duration of ulcers.
Methods: After randomization, sixty nine participants (30 men and 39 women, mean age ± SD: 27.2 ±7.5 years) with RAS were recruited into a test group (group 1) and a control group of 69 RAS patients were also recruited. RAS lesions in group one were exposed to ozone from the healOzone® X4 machine (Curozone, Germany) for 60 seconds while participants in the control group received only air from the same unit through special disposable silicone cups. Ulcer size was recorded for each participant at baseline and daily for 15 days. Pain was assessed with a VAS score from 0 to 10 at study baseline and daily for 15 days. Ulcers duration was determined by recording the time they required to disappear.
Results: No significant relationships were found between age and gender and each of ulcer duration, ulcer size, and pain levels (p>0.05) in both groups except that males had lower ulcer duration than females (p=0.020) in the control group. Ulcer size was significantly reduced starting from the second day in group one and fourth day in controls (p≤0.004). Also, pain levels were significantly reduced starting from the first day in group one and the third day in controls (p≤0.001). Ulcer duration, ulcer size after day 2, pain levels at baseline after ozone application and pain levels from day 1 to 10 were more reduced in group one treated with ozone in comparison to controls.
Conclusions: Application of ozone from the healOzone on RAS lesions for 60 seconds led to a reduction of pain levels as well as enhanced healing of the ulcers by reducing the size and duration of ulcers.