Effects of Cisplantin on peri-implant bone repair

Objectives: The purpose of this study was to evaluate, by comparative histological analysis, the peri-implant bone repair in animals submitted to cisplatins administration.
Methods: Sixty rats (Wistar) undergone surgical procedure to install titanium implants (DSP Biomedical® - 2.2 mm x 4 mm) on their right tibia. The alveoli were prepared using a cutter (2mm) attached to a surgical motor (45N, 980 rpm), under constant irrigation. After surgery the animals were set into two experimental groups (n=30): Group SS – received sodium chloride 0,9% at 15 and 17 days postoperative; Group CIS - cisplatin delivered via intraperitoneal in two doses, the first one with 5 mg/kg and the second with 2,5 mg/kg, at 15 and 17 days postoperative respectively. At 22, 30 and 60 days after installation the animals were euthanized. The collected tibiae were submitted to histological processing, followed by histological analysis of the tissue repair process at peri-implant region. The following parameters were analyzed: nature and degree of inflammation; extension of inflammatory process; presence and extension of tissue necrosis; presence, extension and and nature from bone resorption; state of vasculature; cellularity pattern and structuring of extracellular matrix of the bone, connective and hematopoietic tissues.
Results: The bone neoformation at peri-implant region showed clearly lower on CIS group at every experimental periods. At 22 and 30 days postoperative was still observed persistence of inflammation in some specimens from CIS group.
Conclusions: In conclusion, cisplatin impairs peri-implant bone healing, consequently the osseointegration process.