Method: This study was a randomized, double-blind, two-cell, parallel-group design. Qualifying subjects were randomized into two groups. The two groups were: (1) commercially available Colgate Total Advanced Whitening Toothpaste, Colgate 360 Surround Toothbrush and a mouthwash containing 0.075% CPC in a fluoride-free and alcohol-free base (Test Group) and (2) Colgate Cavity Protection Toothpaste, Colgate Extra Clean Toothbrush and a negative control mouthwash which is both fluoride and alcohol free (Negative Control Group). After brushing, subjects were instructed to rinse with 20 ml for 30 seconds with their assigned mouthwash.
Result: After two weeks of product use, subjects in Test Group exhibited statistically significant (p<0.05) reductions in mean gingival, gingival severity and gingival interproximal index scores of 13.5%, 10.6% and 13.8%, respectively and in mean plaque, plaque severity and plaque interproximal index scores of 16.0%, 26.7% and 14.0%, respectively as compared to the Negative Control Group. The between-group comparison, after four weeks of product use, subjects in Test Group exhibited statistically significant (p<0.05) reductions of 22.3%, 27.8% and 20.4%, respectively in gingival, gingival severity and gingival interproximal index scores and statistically significant (p<0.05) reductions of 28.2%, 60.7% and 27.6%, respectively in plaque, plaque severity and plaque interproximal index scores as compared to the Negative Control Group.
Conclusion: The results of this double-blind clinical study support the conclusions that a statistically significant differences were observed when the Test Group was compared to the Negative Control Group in gingival, gingival severity and gingival interproximal index scores, and plaque, plaque severity and plaque interproximal index scores index scores after two and four weeks of product use.