Method: Subjects were randomly assigned to one of three treatment groups according to their baseline gingival and plaque scores. The three treatment groups were: (1) Colgate® Total® Mouthwash containing 0.075% CPC - fluoride and alcohol free (Test Group), (2) Crest Pro-Health Mouthwash containing 0.075% CPC - fluoride and alcohol free (Positive Control Group) and (3) Placebo Mouthwash - fluoride and alcohol free (Negative Control Group). After brushing, subjects were instructed to rinse their mouth with 20ml of their assigned mouthwash twice daily for thirty seconds.
Result: After six weeks of product use, the Test Group exhibited statistically significant p<0.05) reductions of whole mouth gingival (24.4%), gingival interproximal (25.0%), gingival severity (46.4%), whole mouth plaque (21.5%), plaque interproximal (20.1%) and plaque severity (25.4%) index scores as compared to the Negative Control Group. After six weeks of product use, the Positive Control Group exhibited similar statistically significant (p<0.05) reductions vs. the Negative Control Group. After six weeks of product use, no statistically significant (p>0.05) difference was observed between the Test Group and the Positive Control Group.
Conclusion: The results of this double-blind clinical study support the conclusions that (i) both mouthwashes containing 0.075% CPC - fluoride and alcohol free - provide a significant reduction in dental plaque and gingivitis after six weeks of product use and (ii) no statistically significant (p>0.05) difference was observed between the two CPC-containing mouthwashes in controlling established dental plaque and gingivitis after six weeks of product use.