Instant Dentin Hypersensitivity Reduction Efficacy of Commercially Available Dentifrices

Method: One-hundred-and-fifty adults with confirmed dentin hypersensitivity were assigned to supervised use of one of the three dentifrices.  The use of the arginine toothpaste consisted of a single direct topical application of the toothpaste directly onto the gingivo-facial 1/3 of each of the two study teeth using a fingertip, followed by gently massaging each tooth for sixty seconds. The use of the stannous toothpaste and the fluoride control toothpaste consisted of brushing the two study teeth for 30 seconds each before brushing the remaining teeth for one minute.

Result: Relative to the stannous toothpaste group, subjects in the arginine toothpaste group exhibited statistically significant (P<0.05) improvements in tactile (68.3%) and in air blast hypersensitivity (49.0%) immediately after product use.  Relative to the fluoride control, subjects that brushed with the stannous toothpaste, did not exhibit statistically significant tactile or air blast hypersensitivity improvements (8.3% and 2.8% respectively).

Conclusion:The results of this clinical study demonstrated  instant relief of  dentin hypersensitivity as a result of a single  direct topical application of the toothpaste containing 8% arginine/calcium carbonate compared to a single brushing with the toothpaste containing 0.6% stannous chloride/zinc citrate. In contrast, a single brushing with the 0.6% stannous chloride/zinc citrate toothpaste did not reduce dentin hypersensitivity compared to brushing with the fluoride control toothpaste.