The use of polymerizable MMP inhibitors may offer an advantage over their non-poymerizable counterparts, as they may remain viable in the hybrid layer for longer periods. Objectives: To investigate the resin-dentin bond stability of adhesive interfaces bonded with experimental adhesive blends containing conventional and polymerizable benzalkonium chloride. Methods: Thirty-five healthy molars were used to evaluate experimental blends of a two-step etch-and-rinse adhesive (All Bond Universal, ABU, Bisco Inc) modified either with conventional or polymerizable benzalkonium chloride (BAC or SBAC) in concentrations of 0.5%, 1.0% and 2.0%. All teeth were etched with 37% phosphoric acid (Ultradent Inc.), rinsed, blot dried, and then equally and randomly assigned to seven study groups as follows: 1) ABU with no inhibitor (control); 2) 0.5% BAC-adhesive (0.5% BAC); 3) 1.0% BAC-adhesive (1.0% BAC); 4) 2.0% BAC-adhesive (2.0% BAC); 5) 0.5% SBAC-adhesive (0.5% SBAC); 6) 1.0% SBAC-adhesive (1.0% SBAC); and 7) 2.0% SBAC-adhesive (2.0% SBAC). Microtensile bond strength (μTBS) and nanoleakage were evaluated after 24h and six months of storage in artificial saliva. Beams were immersed in a 50 wt% silver nitrate solution for 24h and then in a photo-developing solution for 8h to reduce silver ions to metallic silver. The specimens were dehydrated and processed for FE-SEM evaluation. A two-way ANOVA and Tukey's test with a significance level of p<0.05 were used for data analysis. Results: A significant effect of the "time" (p=0.022) but no effect of the "treatment" or the interaction "treatment-time" was demonstrated. No significant differences in μTBS values were shown among the treatment groups either at 24 h or six months. Only the control group ABU showed a significant decrease in bond strength after six months (p=0.023). Conclusion: Comparable bond stability can be derived from the use of adhesive blends modified with polymerizable and non-polymerizable BAC when evaluated after six months of storage.