Clinical Investigation of Whitening Efficacy on Colgate Optic White Toothpaste

Methods: Following baseline examinations of tooth color shade and soft tissue, qualified subjects were randomized into two groups (Test and Negative Control), which were balanced for Vita Classical shade guide scores.  Subjects were instructed to brush twice daily (morning and evening) for 1 minute each time.  Tooth shade guide and soft tissue examinations were conducted again after one, two and four weeks of product use.  All examinations were performed under the same lighting condition (interior lighting with blinds closed to block out sunlight), at the same time of day and by the same examiner.

Results: One-hundred subjects entered the study, of which ninety-two subjects complied with the protocol and completed the four week study. The mean tooth shade improvements in Test group at one, two and four weeks were 1.29, 2.38 and 3.24, respectively as compared to baseline, and likewise for the Negative Control group at one, two and four weeks were 0.29, 0.31 and 0.44, respectively.  Thus, Test group provided a statistically significant whitening improvement (1.00, 2.07 and 2.80 respectively) in mean tooth shade as compared to Negative Control group, at one, two and four weeks.  

Conclusion:  The clinical results demonstrated that Colgate Optic White Toothpaste provided a statistically significant tooth whitening improvement as compared to Colgate Cavity Protection Toothpaste after one week, or two weeks or four weeks use.