Methods: Edentuous patients (n=117) received 2 mandibular Straumann implants with Locator attachments supporting existing complete dentures. Assessments taken at baseline (implant surgery), and 6 and 12 months following restoration included Oral health-related quality of life (OHRQoL) using the Oral Health Impact Profile (OHIP-20) questionnaire along with HbA1c levels, BMI, age, gender, ethnicity. Diabetic patients were classified as well-controlled (6.0% Conclusion: This study documents the benefits of implant-supported mandibular overdentures for patients with type 2 diabetes. This study was supported by NIDCR (R01DE017882) with implant materials from Straumann USA.