IADR Abstract Archives
Deciphering Age-Related Molecular Heterogeneity in Oral Squamous Cell Carcinoma
Objectives: Oral squamous cell carcinoma is one of the most common malignancies of the head and neck region. A recent trend indicates an increase in the cases of OSCC in younger individuals under the age of 40 years. The underlying pathogenic mechanism affecting these younger population remains poorly understood. The aim of this study was to compare the clinicopathological and molecular profiles of young and old patients with oral squamous cell carcinoma.
Methods: 180 cases of OSCC were collected from the departmental archives; 90 above the age of 40 years and 90 below the age of 40 years. Clinicodemographic and the survival data were obtained from the departmental records. For molecular analysis, 10 samples (5 from each age group) were pooled and subjected to 50 gene panel next-generation sequencing (NGS).
Results: The mean age was 59.2 years for patients aged more than 40 years and 35.7 years for OSCC patients aged 40 years or below. Both groups exhibited male predominance, with the buccal mucosa being the most common tumor site. The survival data analysis revealed a lower mean survival age for the younger group when compared to older patients. The NGS revealed distinct molecular profiles between the two age groups. Group I showed TP53 (c.328delC) and APC (c.4135G>T) mutations. In contrast, none of the 50 gene mutations analyzed were detected in the younger age group (Group II).
Conclusions: This study highlights the diverse genetic mutations in young and old patients with oral squamous cell carcinoma. The findings will contribute to better treatment planning and effective therapeutic strategies for OSCC patients.
Methods: 180 cases of OSCC were collected from the departmental archives; 90 above the age of 40 years and 90 below the age of 40 years. Clinicodemographic and the survival data were obtained from the departmental records. For molecular analysis, 10 samples (5 from each age group) were pooled and subjected to 50 gene panel next-generation sequencing (NGS).
Results: The mean age was 59.2 years for patients aged more than 40 years and 35.7 years for OSCC patients aged 40 years or below. Both groups exhibited male predominance, with the buccal mucosa being the most common tumor site. The survival data analysis revealed a lower mean survival age for the younger group when compared to older patients. The NGS revealed distinct molecular profiles between the two age groups. Group I showed TP53 (c.328delC) and APC (c.4135G>T) mutations. In contrast, none of the 50 gene mutations analyzed were detected in the younger age group (Group II).
Conclusions: This study highlights the diverse genetic mutations in young and old patients with oral squamous cell carcinoma. The findings will contribute to better treatment planning and effective therapeutic strategies for OSCC patients.