Copper Oxide-Based Antibacterial Compound Synthesis and Characterization - Biomedical Applications
Objectives: This study aims to synthesize and characterize Cu2O nanoparticles. In addition, the antibacterial properties of Cu2O against E. coli and Enterococcus were also investigated. Methods: CuO nanoparticles were synthesized using a chemical precipitation method and calcination at 800°C to obtain a monoclinic crystal structure. Characterization was performed using XRD, HR-TEM, and SAED techniques. Antibacterial activity was assessed against E. coli and Enterococcus through zone of inhibition measurements. Results: XRD analysis shows the single-phase cubic Cu2O with (110), (111) and (220) diffraction peaks [JCPDS file No. 05-0667]. FT-IR shows the presence of surface OH, and the bond between Cu–O it confirms the formation of Cu2O. HRTEM images show the regular particle shape with a size of 50 nm. The synthesized compound showed significant antibacterial activity against E. coli and Enterococcus. Conclusions: Cu2O nanoparticles hold potential in biomedical applications due to their antibacterial properties. However, challenges such as cytotoxicity and stability need to be addressed. Advancements in synthesis and controlled release methods improve their safety and efficiency, making them a promising solution for infection control and regenerative medicine.