IADR Abstract Archives
Literature Review of Histologic Findings in Dental Pulp Regeneration Cases
Objectives: To examine and evaluate existing literature to observe the histological findings of Regenerative Endodontic Treatments (RETs) in addition to their clinical and radiographic observations on human teeth.
Methods: Literature search conducted on PubMed and Embase databases for peer-reviewed human studies from the years 2001 to present day. The criteria for inclusion dictated that only case reports that included clinical, radiographic, and histologic findings would be included in this study. The search terms for this study were as follows: “regenerative AND histologic AND endodontic”. This search retrieved 464 total articles. The articles were screened by two reviewers. Duplicate studies were excluded from the search. Articles were also excluded based on their abstracts. The remaining articles were determined to be included or excluded based on their full-text. Only 17 articles met the criteria for inclusion and therefore included in this study. Each of the 17 articles were analyzed for the patient’s gender, age, and tooth number. The articles were also analyzed for their pulpal and apical diagnosis, choice of irrigant, choice of medicament, choice of scaffold, coronal seal material, final restoration, follow-up period, post-operative clinical findings, and post-operative histologic findings. A results table (Table 1) was created to summarize the results of each individual study selected to be included in this literature review. Variations in technique, methods, and post-operative outcomes were compared to determine if an ideal methodology for optimal RET outcome exists.
Results: The materials, methods, and results of the 17 articles included in this study are summarized in Table 1 and Table 2.
Conclusions: Regenerative endodontic treatment is capable of developing cementum-like tissue. Platelet-Rich Plasma has the potential to be an ideal scaffold and has demonstrated the ability to develop pulp-like tissue. Further clinical studies are needed to determine the ideal technique and outcomes of RETs.
Methods: Literature search conducted on PubMed and Embase databases for peer-reviewed human studies from the years 2001 to present day. The criteria for inclusion dictated that only case reports that included clinical, radiographic, and histologic findings would be included in this study. The search terms for this study were as follows: “regenerative AND histologic AND endodontic”. This search retrieved 464 total articles. The articles were screened by two reviewers. Duplicate studies were excluded from the search. Articles were also excluded based on their abstracts. The remaining articles were determined to be included or excluded based on their full-text. Only 17 articles met the criteria for inclusion and therefore included in this study. Each of the 17 articles were analyzed for the patient’s gender, age, and tooth number. The articles were also analyzed for their pulpal and apical diagnosis, choice of irrigant, choice of medicament, choice of scaffold, coronal seal material, final restoration, follow-up period, post-operative clinical findings, and post-operative histologic findings. A results table (Table 1) was created to summarize the results of each individual study selected to be included in this literature review. Variations in technique, methods, and post-operative outcomes were compared to determine if an ideal methodology for optimal RET outcome exists.
Results: The materials, methods, and results of the 17 articles included in this study are summarized in Table 1 and Table 2.
Conclusions: Regenerative endodontic treatment is capable of developing cementum-like tissue. Platelet-Rich Plasma has the potential to be an ideal scaffold and has demonstrated the ability to develop pulp-like tissue. Further clinical studies are needed to determine the ideal technique and outcomes of RETs.
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