Improved Retention of Well-Fitting Full Maxillary Dentures With Denture Adhesives

Objectives: Improved full denture retention is known to optimise function and confidence. The aim of this study was to investigate the impact of two test denture adhesives on denture retention in well-fitting full maxillary dentures.
Methods: This single-centre, controlled, randomized, examiner--blind, crossover clinical study assessed maximal incisal bite force (BF) before maxillary denture dislodgement over 12 hrs. Positive control was a marketed denture adhesive and negative control was no adhesive. Denture adhesives were applied by a separate examiner.

43 subjects with mean age of 70 years with well-fitting (assessed by Kapur-Olshan Index) maxillary full dentures were evaluated. BF was measured pre-treatment (baseline/ 0 hrs) with no adhesive, and at 0.5, 1, 3, 6, 9, and 12 hrs with the assigned treatment (+/- each denture adhesive). Primary efficacy endpoint was Area over Baseline (AOB) over 12 hrs for incisal BF (natural logged). Positive control AOB_0-12 vs. no adhesive (p<0.05) demonstrated study validity. Subsequently, each test denture adhesive was compared to no adhesive at assigned times.

AOB_0-t for each denture adhesive was analysed by analysis of covariance (ANCOVA). Covariates were subject-specific baseline BF measurements. Pairwise test adhesives vs. no adhesive differences in adjusted means were evaluated with associated Bonferroni-adjusted two-sided p-values.
Results: The results are summarised in the table 1 below.

Additionally, Test denture adhesive 1 was statistically significantly higher for AOB_0-3, AOB_0-6, AOB_0-9 and AOB_0-12 vs. no adhesive. (p<0.05). Test denture adhesive 2 and positive control showed statistically significantly higher AOB vs. no adhesive at every time point.
Conclusions: Results showed significantly improved denture retention for all 3 denture adhesives over 12 hrs versus no adhesive.