IADR Abstract Archives
Anodized vs. Sandblasted Implant Surfaces in Grafted-Dehiscence Defect Animal Model
Objectives: The effect of impact of surface characteristics on osseointegration and bone apposition were investigated by comparing a novel gradient anodised (NGA) functionalized, commercially available, implant (NobelActive™, TiUltra NP, 3.5 × 8.5 mm, Nobel Biocare AG, Switzerland) with custom-made replicas of the NGA implant geometry, modified with the SLActive and SLA surface (Replica of NobelActive, SLActive™ or SLA™, Roxolid, 3.5 x 8.5 mm, Institut Straumann AG, Switzerland).
Methods: Crestal bone formation was analyzed histologically and histomorphometrically using a standardized 3mm acute type buccal dehiscence model grafted with deproteinized bovine bone mineral (DBBM-Bio-Oss™,Geistlich®) and covered with a porcine collagen membrane (Bio-Gide™,Geistlich®) after 2 (2w,n=6) and 8weeks(8w,n=8) of healing. Each animal received one NGA, SLActive and SLA implant. The primary outcome was bone-to-implant contact in the dehiscence defect(dBIC). Secondary outcomes included: first-bone-to-implant-contact(fBIC), new-bone-height(NBH), vertical-bone-creep(VBC) and bone-area-to-total-area(BATA). A multivariate linear regression model, with the factor “animal” modelled as a random effect, was adjusted for multiple comparison using Dunnett-Hsu method with a significance level of α<0.05.
Results: At 2w, dBIC was statistically significantly higher for SLActive(µ=17.1,p<0.05) compared to NGA(µ=2.5). At 8w both SLActive(µ=47.8,p<0.001) and SLA(µ=35.1, p<0.01) demonstrated significantly higher dBIC than NGA(µ=3.2). At both time points, fBIC was significant closer to the crest for SLActive(2w,µ=-14072,p<0.01) (8w,µ=-461.3,p<0.01) and SLA(2w,µ=-1971.5, p<0.05) (8w,µ=-652.1,p<0.01) compared to NGA(2w,µ=-2567.1)(8w,µ=-1633.5). There was significantly more VBC for SLActive(2w,µ=735.6,p<0.05)(8w,µ=1728.2,p<0.01) and SLA(2w,µ=509.0,p<0.05)(8w,µ=1757.9,p<0.01) at 2w and 8w compared to NGA(2w,µ=-69.0)(8w,µ=629.1). At 2w and 8w there was no evidence of a difference(p>0.05) in NBH or BATA between the groups.
Conclusions: At 2 and 8 weeks the SLActive surface demonstrated significantly higher levels of dBIC, fBIC and VBC compared to NGA. SLA surface demonstrated significantly higher levels of fBIC and VBC at 2 weeks and dBIC, fBIC and VBC at 8 weeks compared to the NGA surface.
Methods: Crestal bone formation was analyzed histologically and histomorphometrically using a standardized 3mm acute type buccal dehiscence model grafted with deproteinized bovine bone mineral (DBBM-Bio-Oss™,Geistlich®) and covered with a porcine collagen membrane (Bio-Gide™,Geistlich®) after 2 (2w,n=6) and 8weeks(8w,n=8) of healing. Each animal received one NGA, SLActive and SLA implant. The primary outcome was bone-to-implant contact in the dehiscence defect(dBIC). Secondary outcomes included: first-bone-to-implant-contact(fBIC), new-bone-height(NBH), vertical-bone-creep(VBC) and bone-area-to-total-area(BATA). A multivariate linear regression model, with the factor “animal” modelled as a random effect, was adjusted for multiple comparison using Dunnett-Hsu method with a significance level of α<0.05.
Results: At 2w, dBIC was statistically significantly higher for SLActive(µ=17.1,p<0.05) compared to NGA(µ=2.5). At 8w both SLActive(µ=47.8,p<0.001) and SLA(µ=35.1, p<0.01) demonstrated significantly higher dBIC than NGA(µ=3.2). At both time points, fBIC was significant closer to the crest for SLActive(2w,µ=-14072,p<0.01) (8w,µ=-461.3,p<0.01) and SLA(2w,µ=-1971.5, p<0.05) (8w,µ=-652.1,p<0.01) compared to NGA(2w,µ=-2567.1)(8w,µ=-1633.5). There was significantly more VBC for SLActive(2w,µ=735.6,p<0.05)(8w,µ=1728.2,p<0.01) and SLA(2w,µ=509.0,p<0.05)(8w,µ=1757.9,p<0.01) at 2w and 8w compared to NGA(2w,µ=-69.0)(8w,µ=629.1). At 2w and 8w there was no evidence of a difference(p>0.05) in NBH or BATA between the groups.
Conclusions: At 2 and 8 weeks the SLActive surface demonstrated significantly higher levels of dBIC, fBIC and VBC compared to NGA. SLA surface demonstrated significantly higher levels of fBIC and VBC at 2 weeks and dBIC, fBIC and VBC at 8 weeks compared to the NGA surface.