IADR Abstract Archives
Head and Neck Squamous Cell Carcinoma Presenting as Metastatic Squamous Carcinoma of Unknown Primary in a Colombian Cohort
Objectives: To characterize patients that presented as metastatic Squamous Carcinoma of Unknown primary (CUP) and were diagnosed by core needle biopsy (CNB) or fine needle aspiration cytology (FNA) at Fundación Santa Fe de Bogotá.
Methods: Retrospective analysis of medical record and pathology results of patients diagnosed with Head and Neck Squamous cell Carcinoma belonging to the Colombian cohort from Interchange-Headspace consortium between 2015 and 2022.
Results: Among 156 patients belonging to the cohort, were reviewed and only 33 were diagnosed and/or presented as CUP. Among these 33 patients the mean age was 61.42-year (± 11.24), 66.67% were (n= 22) male and 33.33% were female (n=11) [pr1] [pr2] . Alcohol or tobacco were used by 69.70%. Patients reported attending dental check-ups every year 72.73% (n=24) were frequent, and 24,24% (n=8) were users of some type of oral prosthesis. Diagnosis was made by FNA in 63.64% (n=21) and by CNB in 36.36% (n=12). Nodes were located at level IIA and IIB (90,91%, n=30), level III (6,06%, n=2) and level IA and IB (3,33%, n=1).The primary tumor was located at oropharynx (OP 90.91%, n=30) and oral cavity (OC 9.09%, n=3). Immunohistochemistry for p16 was positive in 84.85% (n=28) of the cases.
Conclusions: Lymphadenopathy is a common sign and symptom of metastatic Squamous Head and Neck carcinoma, corresponding to 21% in our cohort (Vs 5-10% in reported literature). Among these patients 90.91 % were from oropharynx same as reported literature. CUP was the initial symptom of HPV-associated oropharyngeal squamous cell carcinoma (SCC) in 56% of cases (Vs 44 % in reported literature). 70% of our CUP cohort regularly visit dentist office. Awareness of these presentation can aid to detect early carcinomas. CNB and FNA are efficient tools to define and guide the diagnosis of CUP and Immunohistochemistry can be performed in this material as ancillary diagnostic tool.
Methods: Retrospective analysis of medical record and pathology results of patients diagnosed with Head and Neck Squamous cell Carcinoma belonging to the Colombian cohort from Interchange-Headspace consortium between 2015 and 2022.
Results: Among 156 patients belonging to the cohort, were reviewed and only 33 were diagnosed and/or presented as CUP. Among these 33 patients the mean age was 61.42-year (± 11.24), 66.67% were (n= 22) male and 33.33% were female (n=11) [pr1] [pr2] . Alcohol or tobacco were used by 69.70%. Patients reported attending dental check-ups every year 72.73% (n=24) were frequent, and 24,24% (n=8) were users of some type of oral prosthesis. Diagnosis was made by FNA in 63.64% (n=21) and by CNB in 36.36% (n=12). Nodes were located at level IIA and IIB (90,91%, n=30), level III (6,06%, n=2) and level IA and IB (3,33%, n=1).The primary tumor was located at oropharynx (OP 90.91%, n=30) and oral cavity (OC 9.09%, n=3). Immunohistochemistry for p16 was positive in 84.85% (n=28) of the cases.
Conclusions: Lymphadenopathy is a common sign and symptom of metastatic Squamous Head and Neck carcinoma, corresponding to 21% in our cohort (Vs 5-10% in reported literature). Among these patients 90.91 % were from oropharynx same as reported literature. CUP was the initial symptom of HPV-associated oropharyngeal squamous cell carcinoma (SCC) in 56% of cases (Vs 44 % in reported literature). 70% of our CUP cohort regularly visit dentist office. Awareness of these presentation can aid to detect early carcinomas. CNB and FNA are efficient tools to define and guide the diagnosis of CUP and Immunohistochemistry can be performed in this material as ancillary diagnostic tool.