IADR Abstract Archives
Assessment of Correlation Between Dementia and Periodontitis Using BigMouth Database
Objectives: Dementia indicates a decline in cognitive function that interferes with everyday activities including oral health maintenance. Periodontitis is a biofilm induced chronic inflammatory disease characterized by gingival inflammation and alveolar bone loss that may influence systemic inflammation. Given the significant role of chronic inflammation in dementia progression, the purpose of this study was to determine any association between dementia and oral health parameters such as periodontal maintenances and diagnosis, using a multi-institutional dental data repository called BigMouth. This data warehouse gathers a limited dataset from eleven US dental schools that are part of the Consortium for Oral Health Research and Informatics (COHRI).
Methods: Health records from eight US dental schools were obtained following IRB (HSC-DB-21-0437) and COHRI approvals. The experimental group (EG) included subjects with dementia (age > 50) and a comprehensive periodontal exam (N = 148). Dementia diagnosis is patient-reported. The control group (CG) included subjects without dementia and a comprehensive periodontal exam, matched for age, gender, race, smoking status and diabetes (N = 94). EG and CG were compared for differences in the average number of periodontal maintenances, scaling and root planning procedures, osseous and gingival flap surgeries, caries risk and periodontal diagnoses based on 2017 World Workshop classification of periodontal diseases. Chi square, Fisher’s Exact tests and quasi-Poisson regression models were used for statistical analysis (p < 0.05).
Results: Incidence of periodontal maintenances, caries risk, scaling and root planning, gingival flap surgery, and osseous surgery was equivalent in subjects with or without dementia. Significantly higher prevalence of generalized stage II periodontitis (grade A, B, C) was present in the CG group compared to EG (p < 0.05).
Conclusions: Within the limitations of this study, EG and CG groups matched for age, gender, race, smoking and diabetes in BigMouth generally have similar oral health conditions.
Methods: Health records from eight US dental schools were obtained following IRB (HSC-DB-21-0437) and COHRI approvals. The experimental group (EG) included subjects with dementia (age > 50) and a comprehensive periodontal exam (N = 148). Dementia diagnosis is patient-reported. The control group (CG) included subjects without dementia and a comprehensive periodontal exam, matched for age, gender, race, smoking status and diabetes (N = 94). EG and CG were compared for differences in the average number of periodontal maintenances, scaling and root planning procedures, osseous and gingival flap surgeries, caries risk and periodontal diagnoses based on 2017 World Workshop classification of periodontal diseases. Chi square, Fisher’s Exact tests and quasi-Poisson regression models were used for statistical analysis (p < 0.05).
Results: Incidence of periodontal maintenances, caries risk, scaling and root planning, gingival flap surgery, and osseous surgery was equivalent in subjects with or without dementia. Significantly higher prevalence of generalized stage II periodontitis (grade A, B, C) was present in the CG group compared to EG (p < 0.05).
Conclusions: Within the limitations of this study, EG and CG groups matched for age, gender, race, smoking and diabetes in BigMouth generally have similar oral health conditions.