IADR Abstract Archives
Gonadotropins Links to Periodontal Status in Polycystic Ovary Syndrome Patients
Objectives: This study attempted to investigate the association of gonadotropins with periodontal condition, and explore its potential role in PCOS-related periodontitis.
Methods: A total of 39 PCOS patients (27.3±3.7 years, 20-35 years) were recruited at the Shenzhen Maternity & Child Healthcare Hospital (SMCHH) during the period of October 2021 to January 2022. Patients’ demographic characteristics, lifestyles and duration of treatment were assessed and collected from the questionnaires, while the testing results of two common members of gonadotropin family, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels, were retrieved from the dataset of SMCHH. Full-mouth periodontal examination was performed, and individual periodontal status was recorded.
Results: Majority (94.9%) of the patients were never smokers, and 61.5% had monthly household income not less than 20,000 CNY (~USD 3,200). Of note, 43.6% (17/39) of the subjects exhibited periodontitis (Stages I-IV, Periodontitis group), while 38.5% (15/39) of them had gingivitis and 17.9% (7/39) presented with periodontal health (Non-periodontitis group). There was no significant difference in the duration of PCOS treatment between the two groups (3.0 vs 1.5 months, respectively). FSH levels were significantly lower in the Periodontitis group (6.4 IU/L) than those in the Non-periodontitis group (7.7 IU/L, P<0.05). However, there was no notable inter-group difference in LH levels and the ratio of LH/FSH (9.9 IU/L and 1.9 in Periodontitis group vs 12.7 IU/L and 1.6 in Non-periodontitis group). Logistic regression analysis further revealed that FSH was significantly associated with periodontal conditions (OR=0.64, 95% CI: 0.42, 0.98, P<0.05).
Conclusions: This preliminary study suggests that decreased FSH levels may affect periodontal status. Further longitudinal study with a large sample size is needed to clarify the current findings and evaluate the potential clinical implications.
Methods: A total of 39 PCOS patients (27.3±3.7 years, 20-35 years) were recruited at the Shenzhen Maternity & Child Healthcare Hospital (SMCHH) during the period of October 2021 to January 2022. Patients’ demographic characteristics, lifestyles and duration of treatment were assessed and collected from the questionnaires, while the testing results of two common members of gonadotropin family, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels, were retrieved from the dataset of SMCHH. Full-mouth periodontal examination was performed, and individual periodontal status was recorded.
Results: Majority (94.9%) of the patients were never smokers, and 61.5% had monthly household income not less than 20,000 CNY (~USD 3,200). Of note, 43.6% (17/39) of the subjects exhibited periodontitis (Stages I-IV, Periodontitis group), while 38.5% (15/39) of them had gingivitis and 17.9% (7/39) presented with periodontal health (Non-periodontitis group). There was no significant difference in the duration of PCOS treatment between the two groups (3.0 vs 1.5 months, respectively). FSH levels were significantly lower in the Periodontitis group (6.4 IU/L) than those in the Non-periodontitis group (7.7 IU/L, P<0.05). However, there was no notable inter-group difference in LH levels and the ratio of LH/FSH (9.9 IU/L and 1.9 in Periodontitis group vs 12.7 IU/L and 1.6 in Non-periodontitis group). Logistic regression analysis further revealed that FSH was significantly associated with periodontal conditions (OR=0.64, 95% CI: 0.42, 0.98, P<0.05).
Conclusions: This preliminary study suggests that decreased FSH levels may affect periodontal status. Further longitudinal study with a large sample size is needed to clarify the current findings and evaluate the potential clinical implications.