IADR Abstract Archives
Stem Cell Based Therapy for Bone Regeneration: Periodontists and Oral Maxillofacial Clinicians’ Considerations
Objectives: Stem cell based therapy for bone regeneration has received attention in the medical setting, but not in dental and oral maxillofacial settings. The objectives were to explore whether periodontists (P) and oral maxillofacial surgeons (OMFS) had heard about this approach, how they had learned about it, how interested they were to learn about it, which attitudes and behavioral intentions they had related to this approach and what they would like to know before using it.
Methods: 481 members of the American Academy of Periodontology (Response rate: 19.4%) and 541 members of the American Association of Oral and Maxillofacial Surgeons (AAOMS) (Response rate: 21%) responded to surveys.
Results: On average, 24% of the practice of P and 14% of the practice of OMFS (p<0.001) consisted of bone grafting. 35% of P and 26% of OMFS had heard about this approach (p<0.001), mostly from publications (11%/8%) and conferences (10%/5%). Compared to OMFS, P were more interested to learn about this approach in in-person continuing education (CE) courses (5-point scale with 5=very much: Means=4.12/3.54;p<0.001) and OMFS were more interested to learn in online CE courses (4.18/3.91;p<0.001) and from manuals (3.84/3.56;p<0.001). Both groups considered this approach as promising (P:4.07/OMFS:3.98;p=0.127) and preferred it to the traditional approach (P:3.65/OMFS:3.66;p=0.856)). It was important to both groups that this approach would result in more bone volume (4.64/4.69;p=0.281), better bone quality (4.53/460;p=0.122) and accelerated healing (4.31/4.34;p=0.578). The majority in both groups wanted to adopt this approach (P:60.1%/OMFS:54.2%;p=0.207), thought patients would prefer it (P:54.1%/OMFS:48.8%;p=0.134) and it would benefit their practice (P:62.3%/OMFS:56.1%;p=0.137). The highest acceptable cost for growing stem cells ranged widely (Ranges: P:$35-5,000/ $35;OMFS:$50-5,000; Means: $ 535.75/$572.22;p=0.352). When asked what they would like to know about this new approach, research about the short and long-term outcomes and cost and logistics were named frequently.
Conclusions: These findings provide a basis to develop educational interventions for P and OMFS and to inform future research activities needed to address providers’ questions about benefits and challenges of stem cell based therapies for bone regeneration.
Methods: 481 members of the American Academy of Periodontology (Response rate: 19.4%) and 541 members of the American Association of Oral and Maxillofacial Surgeons (AAOMS) (Response rate: 21%) responded to surveys.
Results: On average, 24% of the practice of P and 14% of the practice of OMFS (p<0.001) consisted of bone grafting. 35% of P and 26% of OMFS had heard about this approach (p<0.001), mostly from publications (11%/8%) and conferences (10%/5%). Compared to OMFS, P were more interested to learn about this approach in in-person continuing education (CE) courses (5-point scale with 5=very much: Means=4.12/3.54;p<0.001) and OMFS were more interested to learn in online CE courses (4.18/3.91;p<0.001) and from manuals (3.84/3.56;p<0.001). Both groups considered this approach as promising (P:4.07/OMFS:3.98;p=0.127) and preferred it to the traditional approach (P:3.65/OMFS:3.66;p=0.856)). It was important to both groups that this approach would result in more bone volume (4.64/4.69;p=0.281), better bone quality (4.53/460;p=0.122) and accelerated healing (4.31/4.34;p=0.578). The majority in both groups wanted to adopt this approach (P:60.1%/OMFS:54.2%;p=0.207), thought patients would prefer it (P:54.1%/OMFS:48.8%;p=0.134) and it would benefit their practice (P:62.3%/OMFS:56.1%;p=0.137). The highest acceptable cost for growing stem cells ranged widely (Ranges: P:$35-5,000/ $35;OMFS:$50-5,000; Means: $ 535.75/$572.22;p=0.352). When asked what they would like to know about this new approach, research about the short and long-term outcomes and cost and logistics were named frequently.
Conclusions: These findings provide a basis to develop educational interventions for P and OMFS and to inform future research activities needed to address providers’ questions about benefits and challenges of stem cell based therapies for bone regeneration.