IADR Abstract Archives
Association Between Glucose Metabolism Measures and Periodontal Inflammation Among Pre-Diabetes Patients
Objectives: To investigate the associations of impaired glucose metabolism and insulin resistance with periodontal inflammation among pre-diabetes patients.
Methods: A cross-sectional analysis was conducted and we included a total of 171 pre-diabetes patients aged 30-65 years, free of diabetes. Pre-diabetes was defined as impaired fasting glucose(IFG,FG: 6.1-7.0 mmol/l) and/or impaired glucose tolerance (IGT,OGTT: 7.8-11.0 mmol/l). Periodontal inflammation of the patients were assessed by bleeding on gentle probing (BOP) of the sulcus at six sites per tooth, other periodontal examination indexes (Plaque index（PLI）, probing depth (PD), clinical attachment loss (CAL) and glucose metabolism indexes(Fasting glucose (FG), oral glucose tolerance test (OGTT), HbA1c, fasting insulin and homeostasis model assessments of Insulin Resistance (HOMA-IR)) were measured. The association of glucose metabolism and periodontal inflammation was investigate by binary logistic regressions analysis.
Results: Patients were divided into high BOP group (with the percentage of teeth with bleeding on probing equal to or greater than the median BOP results) and low BOP group((with the percentage of teeth with bleeding on probing less than the median BOP results). PLI, PD and CAL in the in the high BOP group was significantly higher compared to low BOP group, FG and OGTT level in the high BOP group was significantly higher compared to low BOP group, For the insulin HOMA-IR and HbA1c, there was no significant difference between two groups. After logistic regression analysis adjustment of age, gender, smoking status, hypertension and BMI, IFG were associated with high bleeding on probing (OR=1.36，95%CI：1.04-1.76), and OGTT were also associated with high bleeding on probing（OR=1.36，95%CI：1.04-1.76).
Conclusions: Our data provided evidences that impaired glucose metabolism measures were associated with BOP, a marker of periodontal inflammation among pre-diabetes patients.
Methods: A cross-sectional analysis was conducted and we included a total of 171 pre-diabetes patients aged 30-65 years, free of diabetes. Pre-diabetes was defined as impaired fasting glucose(IFG,FG: 6.1-7.0 mmol/l) and/or impaired glucose tolerance (IGT,OGTT: 7.8-11.0 mmol/l). Periodontal inflammation of the patients were assessed by bleeding on gentle probing (BOP) of the sulcus at six sites per tooth, other periodontal examination indexes (Plaque index（PLI）, probing depth (PD), clinical attachment loss (CAL) and glucose metabolism indexes(Fasting glucose (FG), oral glucose tolerance test (OGTT), HbA1c, fasting insulin and homeostasis model assessments of Insulin Resistance (HOMA-IR)) were measured. The association of glucose metabolism and periodontal inflammation was investigate by binary logistic regressions analysis.
Results: Patients were divided into high BOP group (with the percentage of teeth with bleeding on probing equal to or greater than the median BOP results) and low BOP group((with the percentage of teeth with bleeding on probing less than the median BOP results). PLI, PD and CAL in the in the high BOP group was significantly higher compared to low BOP group, FG and OGTT level in the high BOP group was significantly higher compared to low BOP group, For the insulin HOMA-IR and HbA1c, there was no significant difference between two groups. After logistic regression analysis adjustment of age, gender, smoking status, hypertension and BMI, IFG were associated with high bleeding on probing (OR=1.36，95%CI：1.04-1.76), and OGTT were also associated with high bleeding on probing（OR=1.36，95%CI：1.04-1.76).
Conclusions: Our data provided evidences that impaired glucose metabolism measures were associated with BOP, a marker of periodontal inflammation among pre-diabetes patients.