IADR Abstract Archives
Cystic Fibrosis-Related Diabetes and Periodontitis in Adults With Cystic Fibrosis
Objectives: Cystic fibrosis-related diabetes (CFRD) is a unique type of diabetes that affects up to 50% of adults with cystic fibrosis (CF). The prevalence and severity of periodontitis are both significantly higher in adults with diabetes than adults without diabetes. Our previous work indicates that adults with CF are not at greater risk for periodontitis, but it is unknown if CFRD impacts the periodontal health of adults with CF. The goals of this pilot study were to compare the prevalence of periodontitis in adults with CF to non-CF controls, taking into account diabetes status.
Methods: Prospective observational study of adults with CF (age ≥ 18 years) at a single CF Center in Seattle, Washington, USA. CFRD was defined following the American Diabetes Association diagnostic criteria. Periodontitis was defined following the U.S. CDC and the American Academy of Periodontology case definition. We used the 2013-2014 NHANES to form non-CF control groups (with and without diabetes). Non-CF controls were frequency matched to adults with CF on age, sex, diabetes status, and insulin use. Based on CF and diabetes status, we compared periodontitis prevalence across four groups: CFRD, CF and no diabetes, non-CF with diabetes, and non-CF and no diabetes (healthy). We used the Fisher’s exact test for hypotheses testing.
Results: The prevalence of periodontitis for the two CF groups, with and without CFRD, were signficantly higher than healthy controls (CFRD 78% vs. healthy 7%;P<0.001),(CF no diabetes 60% vs. healthy 7%;P=0.001) and not significantly different than non-CF controls with diabetes (CFRD 78% vs. non-CF with diabetes 56%;P=0.43),(CF no diabetes 60% vs. non-CF with diabetes 56%;P=1.0).
Conclusions: Regardless of diabetes status, adults with CF had significantly higher prevalence of periodontitis than healthy controls and similar prevalence to non-CF controls with diabetes. This indicates that CF is a potential risk factor for worse periodontal health despite diabetes status. Additional studies with a larger sample size and prospective control groups are needed to confirm our study findings.
Methods: Prospective observational study of adults with CF (age ≥ 18 years) at a single CF Center in Seattle, Washington, USA. CFRD was defined following the American Diabetes Association diagnostic criteria. Periodontitis was defined following the U.S. CDC and the American Academy of Periodontology case definition. We used the 2013-2014 NHANES to form non-CF control groups (with and without diabetes). Non-CF controls were frequency matched to adults with CF on age, sex, diabetes status, and insulin use. Based on CF and diabetes status, we compared periodontitis prevalence across four groups: CFRD, CF and no diabetes, non-CF with diabetes, and non-CF and no diabetes (healthy). We used the Fisher’s exact test for hypotheses testing.
Results: The prevalence of periodontitis for the two CF groups, with and without CFRD, were signficantly higher than healthy controls (CFRD 78% vs. healthy 7%;P<0.001),(CF no diabetes 60% vs. healthy 7%;P=0.001) and not significantly different than non-CF controls with diabetes (CFRD 78% vs. non-CF with diabetes 56%;P=0.43),(CF no diabetes 60% vs. non-CF with diabetes 56%;P=1.0).
Conclusions: Regardless of diabetes status, adults with CF had significantly higher prevalence of periodontitis than healthy controls and similar prevalence to non-CF controls with diabetes. This indicates that CF is a potential risk factor for worse periodontal health despite diabetes status. Additional studies with a larger sample size and prospective control groups are needed to confirm our study findings.