SYNTHESIS AND CHARACTERIZATION OF POLY (LACTIC ACID)/CHLORHEXIDINE FIBER MEMBRANE SCAFFOLDS

Objectives: The purpose of this study was synthesize and characterize poly-lactic-acid (PLA) / chlorhexidine (CHX) fiber membranes for periodontal applications
Methods: Fiber scaffolds were prepared via air jet spinning (AJS) technique from PLA solutions at 10%. Chlorhexidine was added varying concentration (1%, 0.4%, 0.2% and 0.1%). PLA scaffolds were analyzed using SEM, EDS, FTIR, DSC and TGA. Biocompatibility was evaluated by adhesion and cell proliferation.
Results: FTIR spectra of CHX showed typical biguanide group signals in the 1550–1450 cm−1 region. CHX loaded PLA scaffolds showed biocompatible characteristics for the adhesion and proliferation of human osteoblasts cells for 8 days.
Conclusions: In conclusion, AJS can be an alternative technique for producing a biocompatible CHX loaded PLA fiber scaffold that could be considered for periodontal applications.