IADR Abstract Archives
New Mouthrinse for Orthodontics with Improved Fluoride Deposition and Enamel Remineralization
Objectives: White spot lesions (WSLs) on the teeth surface around the bracket and on the banded area in orthodontic populations is a serious problem, because WSLs can be easily stained with color and quickly lead to deep caries. It was well known that demineralization of tooth enamel resulted from the bacteria accumulation around the bracket and the banded surface was the major cause of the formation of WSLs. However, it is difficult to completely clean the tooth surfaces at the banded surface as well as those around bracket by using the conventional tooth-brushing solely. Therefore, the objective of this work is to develop a new mouthrinse which has improved fluoride deposition and enhanced remineralizing capability in addition to bacteria inhibition, so it could be used as an alternative desirable strategy to prevent or reduce WSLs in orthodontics.
Methods: Due to the restriction for OTC purpose of chlorhexidine by the FDA, the cetylpyridinium chloride (CPC) was selected as the antimicrobial substance for this new mouthrinse. A novel fluoride complex formulated with sodium fluoride and calcium phosphate in a special ratio was developed, in order to improve fluoride deposition and enhance the reminerlizing capability.
Results: While all of the tested mouthrinses have the similar content of total fluoride (250 ppm), the developed mouthrinse with new formulation could deposit fluoride 10-folds more than the selected commercial mouthrinses. More interesting, the enamel remineralized by the new mouthrinse have greater hardness than those from the commercial mouthrinses with similar total fluoride content.
Conclusions: The new mouthrinse with improved fluoride deposition has enhanced remineralizing capability than current commercial mouthrinses. With this new formulation, this new mouthrinse could be an effective mouthrinse to reduce white spot lesions in orthodontics and should have greater potential for caries prevention than those mouthrinses with the similar total fluoride content.
Methods: Due to the restriction for OTC purpose of chlorhexidine by the FDA, the cetylpyridinium chloride (CPC) was selected as the antimicrobial substance for this new mouthrinse. A novel fluoride complex formulated with sodium fluoride and calcium phosphate in a special ratio was developed, in order to improve fluoride deposition and enhance the reminerlizing capability.
Results: While all of the tested mouthrinses have the similar content of total fluoride (250 ppm), the developed mouthrinse with new formulation could deposit fluoride 10-folds more than the selected commercial mouthrinses. More interesting, the enamel remineralized by the new mouthrinse have greater hardness than those from the commercial mouthrinses with similar total fluoride content.
Conclusions: The new mouthrinse with improved fluoride deposition has enhanced remineralizing capability than current commercial mouthrinses. With this new formulation, this new mouthrinse could be an effective mouthrinse to reduce white spot lesions in orthodontics and should have greater potential for caries prevention than those mouthrinses with the similar total fluoride content.
