IADR Abstract Archives
The effect of probiotics in the treatment of periodontal conditions: A systematic review and meta-analysis.
Objectives: The systematic review and meta-analysis aimed to examine the effect of probiotics in the treatment of periodontal conditions.
Methods: The present review is reported based on the PRISMA statement. A systematic search was conducted using Scopus, Web of Science, PubMed, and Cochrane library. The search included randomized clinical trials examining the effect of probiotics in the treatment of periodontal diseases. Predefined criteria were followed to conduct data extraction. The Joanna Briggs Institute critical appraisal tool (JBI) was used for the quality assessment. Study selection, data extraction, and quality assessment were independently conducted by two authors, and disagreements (if any) were resolved by consensus with the third author. Meta-analysis was performed on clinical attachment loss, bleeding on probing (BOP), pocket depth (PD), and plaque index outcome variables for homogenous studies with low risk of bias.
Results: Of 797 identified articles, 39 were included for quality assessment. Using JBI, 23 studies were stratified as low risk of bias. The studies with low risk of bias were heterogeneous as per intervention, review period, and outcome variables. Only four studies were eligible for quantitative synthesis. The effect size estimate at 3-months was not significant (p=0.053) as opposed to the summarized effect size at 6 and 9 months, for the use of probiotic L. rhamnosus SP1 as compared to the controls (p<0.05). Overall summarized effect size for L. rhamnosus SP1 was significantly higher than the placebo for the clinical attachment loss parameter (p<0.001). On the other hand, the effect of L. reuteri (DSM1798 and ATCC PTA5289) on patients with chronic periodontitis at 3-months showed a significant improvement for the following parameters PD (p=0.006) and BOP (p<0.001).
Conclusions: Some probiotics strains significantly improve periodontal conditions when administered perpetually. However, the evidence is supported by very few clinical trials. Further high-quality probiotic strain-specific studies are needed with standardized protocols to conclusively recommend probiotics for the treatment of periodontal diseases.
Methods: The present review is reported based on the PRISMA statement. A systematic search was conducted using Scopus, Web of Science, PubMed, and Cochrane library. The search included randomized clinical trials examining the effect of probiotics in the treatment of periodontal diseases. Predefined criteria were followed to conduct data extraction. The Joanna Briggs Institute critical appraisal tool (JBI) was used for the quality assessment. Study selection, data extraction, and quality assessment were independently conducted by two authors, and disagreements (if any) were resolved by consensus with the third author. Meta-analysis was performed on clinical attachment loss, bleeding on probing (BOP), pocket depth (PD), and plaque index outcome variables for homogenous studies with low risk of bias.
Results: Of 797 identified articles, 39 were included for quality assessment. Using JBI, 23 studies were stratified as low risk of bias. The studies with low risk of bias were heterogeneous as per intervention, review period, and outcome variables. Only four studies were eligible for quantitative synthesis. The effect size estimate at 3-months was not significant (p=0.053) as opposed to the summarized effect size at 6 and 9 months, for the use of probiotic L. rhamnosus SP1 as compared to the controls (p<0.05). Overall summarized effect size for L. rhamnosus SP1 was significantly higher than the placebo for the clinical attachment loss parameter (p<0.001). On the other hand, the effect of L. reuteri (DSM1798 and ATCC PTA5289) on patients with chronic periodontitis at 3-months showed a significant improvement for the following parameters PD (p=0.006) and BOP (p<0.001).
Conclusions: Some probiotics strains significantly improve periodontal conditions when administered perpetually. However, the evidence is supported by very few clinical trials. Further high-quality probiotic strain-specific studies are needed with standardized protocols to conclusively recommend probiotics for the treatment of periodontal diseases.
