Bone Healing in Defects Treated with Platelet-Rich Plasma and Platelet-Poor Plasma

Objectives: The aim of this study is to verify the effects of highly concentrated platelet-rich plasma (hPRP) and platelet-poor plasma (PPP) in bone repair using non-critical defects in the calvaria of rabbits.
Methods: Different groups were analyzed in the 2nd, 4th and 6th week postoperatively: autogenous particled bone (APB) (group 1), APB associated with hPRP (group 2), APB associated with PPP (+ PPP, group 3), isolated PPP (PPP, group 4) and blood clot (Control, group 5). Histological and histomorphometric analysis were carried through.
Results: After two weeks, group 5 showed 71,59% of the defects volume filled with granulation tissue, and group 4 showed 47,24%. After four weeks, the amounts of mature bone were higher in the APB group, and the presence of medular area was higher in the Control group. And the groups that used hPRP or PPP, showed higher levels of granulation tissue. After six weeks, greater formation of mature bone was found in the group 1. The groups 3 and 4, after four weeks, still showed significant granulation tissue values filling the defects.
Conclusions: In conclusion, hPRP and the PPP were not effective in association with autogenous particled bone. Similary, isolated use of PPP was not beneficial in optimizing the bone repair.