IADR Abstract Archives
Biomechanical Role of Trabecular Microstructure on Peri-Implant Strain
Objectives: The study aimed to evaluate the influence of age and trabecular microstructure on peri-implant strain.
Methods: The study was approved by Loma Linda University Institutional Animal Care and Use Committee (IACUC). Eighteen female C57BL/6 mice, 4-week old (n=6) were subjected to 1.2% calcium (young high calcium group, YH), and 7-month old (n=12) randomly to 0.01% and 1.2% calcium (aging low and aging high calcium groups, AL and AH) diet for three weeks. The histomorphometric and micro-CT analysis were used to evaluate local alveolar bone microstructure. One maxilla segment from each group was reconstructed using micro-CT images. The finite element analysis (FEA) based on computational models of maxilla segment with trabecular microstructure was performed. Implants with three different diameters (0.3 mm, 0.4 mm, and 0.5 mm) were analyzed in these models.
Results:
AL group showed worse cancellous microstructure in HE staining as well as significantly increased osteoclast numbers (p < 0.05), and reduced bone volume fraction and trabecular thickness compared to AH group (p < 0.05). However, YH group presented no difference in trabecular microstructure and osteoclast numbers compared to AH group. AL group demonstrated high strain concentration and increased strain intensity compared to AH group, whereas YH and AH groups showed comparable strain magnitude. When the diameter increased from 0.3 mm to 0.4 mm, the percentages of pathological overload decreased regardless of bone microstructure.
Conclusions: A low calcium diet induces bone deterioration that markedly impacts trabecular microstructure which in turn affects strain distribution; however, whenever aging has no significant effect on trabecular microstructure, consequently no substantial influence on peri-implant strain. The trabecular microstructure is the direct risk factor for dental implants. Clinical decision-making should take into consideration the patient-specific and site-specific trabecular microstructure with the use of high-resolution cone beam computed tomography in preoperative assessment.
Methods: The study was approved by Loma Linda University Institutional Animal Care and Use Committee (IACUC). Eighteen female C57BL/6 mice, 4-week old (n=6) were subjected to 1.2% calcium (young high calcium group, YH), and 7-month old (n=12) randomly to 0.01% and 1.2% calcium (aging low and aging high calcium groups, AL and AH) diet for three weeks. The histomorphometric and micro-CT analysis were used to evaluate local alveolar bone microstructure. One maxilla segment from each group was reconstructed using micro-CT images. The finite element analysis (FEA) based on computational models of maxilla segment with trabecular microstructure was performed. Implants with three different diameters (0.3 mm, 0.4 mm, and 0.5 mm) were analyzed in these models.
Results:
AL group showed worse cancellous microstructure in HE staining as well as significantly increased osteoclast numbers (p < 0.05), and reduced bone volume fraction and trabecular thickness compared to AH group (p < 0.05). However, YH group presented no difference in trabecular microstructure and osteoclast numbers compared to AH group. AL group demonstrated high strain concentration and increased strain intensity compared to AH group, whereas YH and AH groups showed comparable strain magnitude. When the diameter increased from 0.3 mm to 0.4 mm, the percentages of pathological overload decreased regardless of bone microstructure.
Conclusions: A low calcium diet induces bone deterioration that markedly impacts trabecular microstructure which in turn affects strain distribution; however, whenever aging has no significant effect on trabecular microstructure, consequently no substantial influence on peri-implant strain. The trabecular microstructure is the direct risk factor for dental implants. Clinical decision-making should take into consideration the patient-specific and site-specific trabecular microstructure with the use of high-resolution cone beam computed tomography in preoperative assessment.
