IADR Abstract Archives
Clinical Investigation on Enzyme Whitening Toothpaste
Objectives: The aim of the four-week clinical study was to investigate whitening efficacy of the Enzyme Whitening Toothpaste (Test) compared to Colgate Cavity Protection Toothpaste (Negative Control).
Methods: Following prophylaxis, and baseline examinations of tooth color shade and soft tissue, qualified subjects were randomized into two groups (Test and Negative Control), which were balanced for Extended Bleachedguide scores. Subjects were instructed to use products twice daily (morning and evening), two minutes each time of brushing. Tooth shade guide and soft tissue examinations were conducted again after four weeks of product use. All examinations were performed under the same lighting condition by the same examiner.
Results: Eighty subjects entered the clinical study, of which seventy-six subjects complied with the protocol and completed the clinical study. Four subjects who didn't complete the clinical study was not related to the test products, rather relocations. There was no adverse event associated with the clinical study. The mean tooth shade scores in Test group at baseline and four weeks were 18.26 and 15.73, respectively, and likewise for Negative Control group at baseline and four weeks were 18.39 and 18.11, respectively. Thus, Test group provided statistically significant whitening improvements compared to baseline (2.54 shade change) and Negative Control group (0.27 shade change) at four weeks, respectively.
Conclusions: The clinical results supported the conclusion that after four weeks of product use, the Enzyme Whitening Toothpaste provided statistically significant more intrinsic whitening efficacy than Colgate Cavity Protection Toothpaste.
Methods: Following prophylaxis, and baseline examinations of tooth color shade and soft tissue, qualified subjects were randomized into two groups (Test and Negative Control), which were balanced for Extended Bleachedguide scores. Subjects were instructed to use products twice daily (morning and evening), two minutes each time of brushing. Tooth shade guide and soft tissue examinations were conducted again after four weeks of product use. All examinations were performed under the same lighting condition by the same examiner.
Results: Eighty subjects entered the clinical study, of which seventy-six subjects complied with the protocol and completed the clinical study. Four subjects who didn't complete the clinical study was not related to the test products, rather relocations. There was no adverse event associated with the clinical study. The mean tooth shade scores in Test group at baseline and four weeks were 18.26 and 15.73, respectively, and likewise for Negative Control group at baseline and four weeks were 18.39 and 18.11, respectively. Thus, Test group provided statistically significant whitening improvements compared to baseline (2.54 shade change) and Negative Control group (0.27 shade change) at four weeks, respectively.
Conclusions: The clinical results supported the conclusion that after four weeks of product use, the Enzyme Whitening Toothpaste provided statistically significant more intrinsic whitening efficacy than Colgate Cavity Protection Toothpaste.