IADR Abstract Archives
The effect of non-tobacco-based nicotine pouch on dental plaque characteristics.
Objectives: The aim of the study was to assess the effect of non-tobacco-based nicotine pouch (ZYN®) on dental-biofilm acidogenicity (short and long term) and amount. The ZYN® pouch is an alternative form of orally delivered nicotine in which matrix consists of maltitol and cellulose microcrystals instead of ground tobacco leaves. Maltitol and cellulose are not usually associated with changes in biofilm acidogenicity, however, the prolonged exposure (30-60 min) during the use of the product may cause vulnerability and caries risk.
Methods: The study consisted of 2 parts. Ethical approval and informed consent were obtained from each participant. Part 1 was an open, randomized, 4-way crossover, single administration trial on 18 subjects. Flavoured and unflavoured brand of nicotine pouch, 10% sucrose and 10% xylitol (controls) was tested. The nicotine pouch was kept in the vestibule for 60min and the controls were rinsed in the mouth for 1min, respectively. Part 2 was an open, observational, follow-up study for 6 weeks on 57 subjects. Exposure to 10% sucrose was tested at baseline and after 2, 4, 6 weeks of pouch use. Dental plaque acidogenicity was measured on 2 buccal and 2 approximal surfaces in the upper-jaw at baseline and up to 60min after administration using the microtouch method. The plaque amount was scored (0-3) on 6 tooth-sites.
Results: After single-dose administration (Part 1), AUC7.5 for dental plaque acidogenicity was significantly smaller for the ZYN® products and xylitol compared to sucrose. There were no statistical differences between different ZYN® products. After ad libitum administration of nicotine-containing pouches (Part 2), AUC7.0 for plaque acidogenicity during the study was significantly reduced compared to baseline. No statistically significant changes in plaque amount were observed during the 6-week study.
Conclusions: Dental plaque acidogenicity significantly decreased in healthy snus users after 6-week ad libitum administration of non-tobacco-based nicotine pouches (ZYN®).
Methods: The study consisted of 2 parts. Ethical approval and informed consent were obtained from each participant. Part 1 was an open, randomized, 4-way crossover, single administration trial on 18 subjects. Flavoured and unflavoured brand of nicotine pouch, 10% sucrose and 10% xylitol (controls) was tested. The nicotine pouch was kept in the vestibule for 60min and the controls were rinsed in the mouth for 1min, respectively. Part 2 was an open, observational, follow-up study for 6 weeks on 57 subjects. Exposure to 10% sucrose was tested at baseline and after 2, 4, 6 weeks of pouch use. Dental plaque acidogenicity was measured on 2 buccal and 2 approximal surfaces in the upper-jaw at baseline and up to 60min after administration using the microtouch method. The plaque amount was scored (0-3) on 6 tooth-sites.
Results: After single-dose administration (Part 1), AUC7.5 for dental plaque acidogenicity was significantly smaller for the ZYN® products and xylitol compared to sucrose. There were no statistical differences between different ZYN® products. After ad libitum administration of nicotine-containing pouches (Part 2), AUC7.0 for plaque acidogenicity during the study was significantly reduced compared to baseline. No statistically significant changes in plaque amount were observed during the 6-week study.
Conclusions: Dental plaque acidogenicity significantly decreased in healthy snus users after 6-week ad libitum administration of non-tobacco-based nicotine pouches (ZYN®).