IADR Abstract Archives
The Effects of Desensitizers on Adhesive-dentin Bonding Strength
Objectives: This study was a systematic review of literatures in vitro and vivo studies which evaluated the effects of desensitizers on bond strength of adhesive-dentin.
Methods: Two researchers selected studies, extract data and assess risk of bias respectively. The search was done in 4 databases (PUBMED, Embase, Web of Science and Cochrane) without publication date or language limits. In addition, the inclusion criteria were to evaluate the effect of instant or aging bond strength after applying the desensitizer in the bonding step. We only do mata-analysis for studies adding desensitizing agent in the bonding step. And analysis was under a random effects model. In this way, we compared the bonding strength of desensitizing agent in self-etching adhesive and etch-and-rinse adhesive. We also did meta-analysis to compare the characters of the same type desensitizer in different etching system.
Results:
1636 articles were found by our search strategy, 59 studies were selected for full-text analysis, and 32 were systematically reviewed, with 18 considered in the meta-analysis And the results showed that there was a significant difference among different kinds of desensitizers. Moreover, subgroup comparison was highly heterogeneous(P<0.00001). Only 1 paper(3.125%) showed a low risk of bias, while all others showed either medium(90.625%) or high(6.25%) risk of bias in included studies. Varies of desensitizers have different effects on the microtensile strength. The use of CPP-ACP and Arginine-CaCO3 showed no negative impact on the immediate bond strength, while other desensitizers (BisBlock, Novamin, Super Seal) might did.
Conclusions: Varies of desensitizers have different effects on the microtensile strength of dentin-adhesive interface. And there is considerable heterogeneity among different brands of adhesives. Due to the deficiency of clinical data, further research is urgently required to further confirm the effect of desensitizers on the bond strength.
Methods: Two researchers selected studies, extract data and assess risk of bias respectively. The search was done in 4 databases (PUBMED, Embase, Web of Science and Cochrane) without publication date or language limits. In addition, the inclusion criteria were to evaluate the effect of instant or aging bond strength after applying the desensitizer in the bonding step. We only do mata-analysis for studies adding desensitizing agent in the bonding step. And analysis was under a random effects model. In this way, we compared the bonding strength of desensitizing agent in self-etching adhesive and etch-and-rinse adhesive. We also did meta-analysis to compare the characters of the same type desensitizer in different etching system.
Results:
1636 articles were found by our search strategy, 59 studies were selected for full-text analysis, and 32 were systematically reviewed, with 18 considered in the meta-analysis And the results showed that there was a significant difference among different kinds of desensitizers. Moreover, subgroup comparison was highly heterogeneous(P<0.00001). Only 1 paper(3.125%) showed a low risk of bias, while all others showed either medium(90.625%) or high(6.25%) risk of bias in included studies. Varies of desensitizers have different effects on the microtensile strength. The use of CPP-ACP and Arginine-CaCO3 showed no negative impact on the immediate bond strength, while other desensitizers (BisBlock, Novamin, Super Seal) might did.
Conclusions: Varies of desensitizers have different effects on the microtensile strength of dentin-adhesive interface. And there is considerable heterogeneity among different brands of adhesives. Due to the deficiency of clinical data, further research is urgently required to further confirm the effect of desensitizers on the bond strength.
