IADR Abstract Archives
Effectiveness of New Isomalt-containing Toothpaste Formulations in Preventing Caries Development
Objectives: This study investigated the effectiveness of Isomalt-containing toothpaste to prevent caries development, compared with sodium fluoride toothpaste (1100 ppm fluoride).
Methods: 180 tooth blocks were randomly assigned to six experimental groups (30 blocks/group): De-ionized distilled water (A), and toothpaste containing either 10% Isomalt plus 1100ppm fluoride and 0.05% cetylpyridinium chloride (B), 10% Isomalt plus 1100ppm fluoride (C), 10% Isomalt plus 1100ppm fluoride and 1.5% Sodium lauryl sulfate (SLS) (D), 1100ppm fluoride only (E), or 1100ppm fluoride with SLS (F). The six groups were subjected to 7-day demineralization by plaque growth in a multispecies Microbial Caries Model. Toothpastes were applied as slurries of 1 part toothpaste and 3 parts DDW twice daily for 2 minutes. Demineralization was assessed using Surface Microhardness testing for change in SMH (△SMH) and Transverse Microradiography (TMR) for mineral loss (△Z). Paired t-test was used for intra-group comparison in SMH and ANOVA followed by Tukey’s test for intergroup comparisons in △SMH and △Z. All p-value are considered significant if <0.05.
Results: With SMH, relative to sound enamel baseline, paired t-test showed significant (P<0.001) demineralization in groups A, C, D, E and F but not in B. Intergroup comparison using %△SMH showed significantly (Tukey’s; p<0.001) greater demineralization in group A compared to all treatment groups; however, there was a significantly (P<0.001) greater demineralization in groups C, E and F compared to B but no significant difference between D and B or E. For TMR data, relative to group A, all groups significantly (p<0.0001) inhibited demineralization at varying percentages; however, all comparisons of the groups with each other were significant (p<0.0001), except group C and E or F.
Conclusions: This study demonstrated toothpaste containing 10% Isomalt with 1100ppm fluoride and 0.05% CPC to be more effective in preventing caries development in the presence of dental plaque than toothpaste with only 1100ppm fluoride.
Methods: 180 tooth blocks were randomly assigned to six experimental groups (30 blocks/group): De-ionized distilled water (A), and toothpaste containing either 10% Isomalt plus 1100ppm fluoride and 0.05% cetylpyridinium chloride (B), 10% Isomalt plus 1100ppm fluoride (C), 10% Isomalt plus 1100ppm fluoride and 1.5% Sodium lauryl sulfate (SLS) (D), 1100ppm fluoride only (E), or 1100ppm fluoride with SLS (F). The six groups were subjected to 7-day demineralization by plaque growth in a multispecies Microbial Caries Model. Toothpastes were applied as slurries of 1 part toothpaste and 3 parts DDW twice daily for 2 minutes. Demineralization was assessed using Surface Microhardness testing for change in SMH (△SMH) and Transverse Microradiography (TMR) for mineral loss (△Z). Paired t-test was used for intra-group comparison in SMH and ANOVA followed by Tukey’s test for intergroup comparisons in △SMH and △Z. All p-value are considered significant if <0.05.
Results: With SMH, relative to sound enamel baseline, paired t-test showed significant (P<0.001) demineralization in groups A, C, D, E and F but not in B. Intergroup comparison using %△SMH showed significantly (Tukey’s; p<0.001) greater demineralization in group A compared to all treatment groups; however, there was a significantly (P<0.001) greater demineralization in groups C, E and F compared to B but no significant difference between D and B or E. For TMR data, relative to group A, all groups significantly (p<0.0001) inhibited demineralization at varying percentages; however, all comparisons of the groups with each other were significant (p<0.0001), except group C and E or F.
Conclusions: This study demonstrated toothpaste containing 10% Isomalt with 1100ppm fluoride and 0.05% CPC to be more effective in preventing caries development in the presence of dental plaque than toothpaste with only 1100ppm fluoride.
