Method: 45 rats were divided in 3 groups and received 0.2 mL of Ropi, Ropi-HP-BCD and Ropi-Epi as IANB, near to the right mandibular foramen; the left side received the respective controls (saline or 2-hydroxypropil-β-cyclodextrin solution). Success and duration of anesthesia were evaluated by electric stimulation (pulp tester) applied to copper wires attached to the mandibular molars. Data were submitted to Log-Rank, Kruskal-Wallis, and Student-Newman-Keuls tests (α=5%).
Result: Anesthesia onset, success and duration are presented on table. No differences in anesthesia onset were observed among formulations (p>0.05). Ropi-Epi provided higher anesthesia success and duration than Ropi-HP-BCD and Ropi (p<0.05), which did not differ from each other (p>0.05).
|
Ropi |
Ropi-HP-BCD |
Ropi-Epi |
Anesthesia onset (mean ± interquartile range, min) |
4±2 |
4±4 |
2±2 |
|
|||
Anesthesia duration (mean ± interquartile range, min) |
15±20 |
20±5 |
50±15 |
|
|||
Anesthesia success (%) |
|||
At 20min |
20 |
53 |
100 |
At 50min |
0 |
0 |
67 |
Conclusion: Pulpal anesthesia is improved by association of ropivacaíne to epinephrine. The complexation with 2-hydroxypropil-β-cyclodextrin did not improve ropivacaine efficacy in pulpal anesthesia in the rat inferior alveolar nerve block model.