IADR Abstract Archives
HPV local immunosuppression predisposes Candida albicans oral infection?
Human papillomaviruses (HPV) are epitheliotropic DNA viruses that infect basal layer cell and induce hyperplastic, papillomatous, verrucous and sometimes malignant lesions in the skin and mucosae. Low-risk types, such as HPV 6 and 11 are associated with benign lesions like: squamous papilloma, condyloma acuminatum, verruca vulgaris and focal epithelial hyperplasia. Some studies suggested that the infection with HPV can cause a local imunosupression. Candidiasis is an opportunistic fungal infection caused by the yeast from Candida albicans gender restrict to skin and mucous membranes, with this infection, in some cases, associated to vaginal infection by HPV. There are no reports in literature about this coinfection in oral lesions.
Objective: The aim of this study was investigate the presence of HPV and Candida albicans coinfection in 50 oral benign HPV-related lesions of the archives of the Surgical Pathology Service of University of São Paulo.
Method: With this proposal, HPV presence was analyzed through conventional PCR technique and Candida albicans identified by PAS.
Result: Our results showed a coinfection of HPV and Candida albicans in 12%(7cases) of all benign HPV-related lesions.
Conclusion: These results suggest a possible relation of Candida albicans infection and local immunosuppression caused by HPV.