IADR Abstract Archives
Effect of subgingival ELVAX/echistatin implants on extracted andreimplanted teeth
Objective: investigate the effect of subgingival ELVAX implants with echistatinon the dental resorptive process in reimplantation of upper incisors in rats.Methods: 42 animals were divided into groups with and without echistatin.Extra alveolar socket period was 30 and 60 minutes and post-surgical experimental periods were 15, 60 and 90 days. Specimens were processed and stained with H.E.. Two examiners performed a quantitativehistomorphometric and descriptive evaluation of the events. The inflammatory response was evaluated as well as incidence of resorptions or ankylosis.Results: agreement between examiners determined by the Kappa index, proved to be almost perfect for all variables. The comparison between the experimental and control groups was performed using the Mann-Whitney test,showed no statistical difference between the administration of echistatin andextra alveolar socket period relative to the inflammatory intensity in different portions of the root. Regarding the type of resorption, it was noted that the presence of inflammatory resorption was significantly higher (p <0.05) in the control group on days 30 and 60 minutes in the postoperative period of 15 days. Ankylosis was significantly more prevalent in the group treated withechistatin in extra alveolar socket period of 30 minutes and 15-day trial period. There was even more ankylosis in control group with 60 minutes of extra alveolar socket, with the trial period of 60 days. In the trial period of 90 days all specimens studied featured inflammatory reabsorptives processes and absence ankylosis. The Kruskal-Wallis test assessed significant differences between groups in relation to the intensity of inflammation by root third,resorption type of and ankylosis. Individual comparisons were performed with Dunn test and showed significant differences between groups. Conclusions: subgingival ELVAX implants with echistatin shown to have therapeutic potential in preventing the inflammatory reabsorptive process caused by reimplantationof upper incisors in rats.