Method: 24 rats (8/group) received 0.1mL of articaine formulations as IONB in the right side and the respective control at the left side. 36 rats (6/group) received 0.1mL of articaine formulations and the controls in the inflamed right hind paw (surgical wound and suture) . Anesthesia parameters were evaluated by upper lip pinching (IONB) and force application by von Frey anesthesiometer (SISW). Data were submitted to Log-Rank, Kruskal-Wallis and Student-Newman-Keuls tests (α=5%).
Result: IONB: Arti-Epi provided higher duration than Arti-LUV (p<0.05); Arti-MLV did not differ from the others (p>0.05); Arti-LUV provided lower success than the others (p<0.05). SISW: Arti-Epi presented higher duration and success (p<0.05) than the liposomal formulations. IONB x SISW: success and duration were lower in SISW than IONB for Arti-MLV and Arti-LUV (p<0.05).
Table. Success (%) and duration (median and interquartile range, in minutes) of anesthesia.
|
IONB |
SISW |
||||
|
ArtiEpi |
ArtiMLV |
ArtiLUV |
ArtiEpi |
ArtiMLV |
ArtiLUV |
Anesthesia duration (min) |
162.5±17.5 |
140±62.5 |
140±31.25 |
150±67.5 |
65±17.5 |
55±17.5 |
Anesthesia success (%) |
||||||
At 70min |
100 |
100 |
100 |
100 |
50 |
33 |
At 145min |
100 |
62.5 |
25 |
67 |
0 |
0 |
Conclusion: In non-inflamed tissues Arti-MLV was equivalent to Arti-Epi. In inflamed tissues Arti-Epi provided higher success and duration. Inflammation decreased anesthesia success and duration for liposomal articaine formulations but not for articaine with epinephrine.