Method: In this retrospective analysis, 10 critical sized jaw discontinuities(caused by segmental resection for aggressive benign pathologies) that were treated with rhBMP2-BG along with reconstruction plates(Group1) and similar cases that were rehabilitated using TDO(Group2). Only cases that were followed up for a period of more than 25weeks or completion of consolidation period as the case may be were included for study.
Predictor Variables: type of treatment
Outcome Variables: time, blood loss, drugs usage, efficiency of bone deposition (radiological) at 25th Week, Complications.
Statistics: Performed using SPSS 16.0. Descriptive statistics, one way ANOVA. p<0.05 taken as significant.
Result: Two(20%) device failures and one hour-glass deformity(10%, premature consolidation) were seen in group2. Cases with long defects and crossing midlines had better success with group1. The length of surgery in group1 was 71.5±23.16 and group2 was 132.8±12.74minutes(p =0.000) while total surgery time was 91.7±23.68 minutes in group1 and 188.8±8.92minutes in group2(p=0.000). Similarly use of medications, pain (measured by VAS), duration of work lost and regain of functional abilities were significantly different(p <0.05), in favor of group1. The mean efficacy of bone formation radiologically was 95.39±1.61% in group1 while it was 87.29±4.25% in group2. The difference was significantly different.(p=0.000). As expected the length of hospital stay was minimum in group1.
Conclusion: Outcome measures of treatment of critical sized defects with rhBMP2-BG had been compared against TDO. Treatment with rhBMP2-BG had good establishment of Mandibular continuity with early recovery, patient comfort, short hospital stay, less morbidity, cost efficacy and no need for second surgery.