IADR Abstract Archives

Cytokine Expression In Human During Accelerated Tooth Movement

Objective: Previously we have shown that microperforations (MP) in rat maxila, increase the expression of many cytokines (IC) and bone remodeling (BR) markers which was accompanied by accelerated tooth movement (TM). It was not clear if the same reaction would be observed in humans. The objective of this project was to conduct a pilot study to map the cytokine expression in humans in response to MP.

Method: After IRB approval, 12 adults with class II skeletal pattern enrolled in the study. In a split mouth design canines were retracted bodily in presence or absence of MP. TM was measured in the casts. Expression of IC and BR markers were measured in gingival crevicular fluid at different time intervals.

Result: MP caused accelerated tooth movement and an increase in expression of IC and BR markers that varied with time.

Conclusion: Similar to rats, MP increased expression of different IC and BR markers that was accompanied by a significant increase in the rate of bone remolding and TM in humans.

Division: IADR/LAR General Session
Meeting: 2012 IADR/LAR General Session (Iguaçu Falls, Brazil)
Location: Iguaçu Falls, Brazil
Year: 2012
Final Presentation ID: 3122
Abstract Category|Abstract Category(s): Craniofacial Biology

Authors

Park, Hyunjung ( New York University, New York, NY, USA )

Raptis, Markos ( New York University, New York, NY, USA )

Khoo, Edmund ( New York University, New York, NY, USA )

Teixeira, Cristina ( New York University, New York, NY, USA )

Alikhani, Mani ( New York University, New York, NY, USA )

SESSION INFORMATION

Oral Session
Orthodontic Treatment Effects and Outcomes
06/23/2012