Keynote Address: Remineralization: Saliva and Salivary Enhancers

The process of remineralization can be considered the reverse of demineralization in that it restores lost mineral to the tissue being studied. As shown by early researchers in this area, fluoride enhanced the remineralization process but was not necessary for it to occur. In the caries process the formation of white spot lesions and subsurface demineralization in enamel show that more than demin/remin of a solid is taking place. Structural, bacterial, dietary, and kinetic factors are also having a role. Since calcium and phosphate are the main building blocks in both demineralization and remineralization their presence and concentration is very important. When salivary flow is compromised then so is the amount of calcium/phosphate and the need for “salivary enhancers” becomes evident. The results expected from remineralization and the agents that may enhance remineralization will be discussed.