Objective: This study investigated the influence of SeLECT Defense Primer (SDP) and SeLECT Defense Enamel Surface Sealant (SDS) on shear bond strength (SBS) of bonded bracket, comparing them with other existing products. Methods: 150 teeth were randomly assigned to 10 groups. Group A: Leopard Primer (LP) vs SeLECT Defense adhesive (SDA), Group B: LP and Transbond XT adhesive (TBA), Group C: SDP vs SDA, Group D: SDP vs TBA, Group E: SDS vs SDA, Group F: SDS vs TBA, Group G: Pro-Seal (PS) vs SDA, Group H: PS vs TBA, Group I: PS vs SDA, Group J: Opal-Seal (OS) vs TBA. Central portion of the buccal surface of each tooth was polished flat, and a bracket bonded onto it following the manufacturer's instruction. After 24 hours storage in water in an incubator at 37ºC, each specimen was positioned in an Instron machine, and the bonding interface was loaded in shear with a crosshead speed of 0.5 mm/min until failure. Shear bond MPa (MN/m2) at which failure occurred was recorded. Results: Data were analyzed by 2-way factorial analysis of variance (α=0.05). One factor represents type of sealant with five levels, and the other factor represents type of adhesive with 2 levels. In the omnibus analysis all effects were statistically significant at the p<0.05 level (main effect of sealant: F(4,140)=3.94, p=0.005; main effect of adhesive: F(1,140)=45.63; sealant by adhesive interaction: F(4,140)=3.16, p=0.016. Sealant by adhesive interaction was further explored by analyzing the simple main effect of adhesive at each level of sealant. This analysis shows that for all sealants, except OS, the SBS of TBA is significantly (P<0.05) stronger than that of SDA. Conclusion: This study demonstrated that with all sealants and primers, both TBA and SDA exhibited SBS adequate and beyond the recommended value (5-8 MPa) for routine orthodontic practice.