Instant Sensitivity Relief of a Stannous-containing Sodium fluoride Dentifrice

Objectives: To evaluate the effect of a Stannous-containing sodium fluoride dentifrice in the reduction of dentinal hypersensitivity relative to a negative control. Methods: This was a 3-day, parallel-group, examiner-blind, randomized and controlled clinical trial. A total of 88 healthy adults with at least two teeth demonstrating moderate hypersensitivity were enrolled into the study. Following baseline examinations, subjects were randomly assigned to one of the two test products: an experimental Stannous-containing sodium fluoride dentifrice (0.321% Sodium fluoride) or a negative control dentifrice (Colgate Cavity Protection®). Subjects performed their first product use on site and then used the product at home, according to the manufacturer's usage instruction, twice daily over the 3-day period. Subjects in the experimental dentifrice group brushed the sensitive tooth first for 30 seconds. Safety and efficacy (tactile evaluation using Yeaple Probe by an experienced examiner and thermal evaluations based on Schiff Air Index by the same examiner and Visual Analog Scale -VAS by the study subjects) measurements were made at Baseline and Day 3. Immediately following the first product application, thermal evaluations were performed to allow for instant sensitivity relief assessment. All statistical comparisons were two-sided at the 0.05 level of significance. Results: Immediately following the first product application, the experimental dentifrice resulted in statistically significantly lower mean thermal sensitivity scores as assessed by both the examiner (p=0.0004) and the study subjects (p<0.0001) when compared to the negative control. At Day 3, the experimental dentifrice provided statistically significantly lower mean thermal sensitivity scores (p<0.0001 for both Schiff air index and VAS) and significantly higher pressure tolerance (p<0.0001 for Yeaple probe) against the negative control. All test products were well tolerated. Conclusions: The research demonstrated the instant hypersensitivity relief benefit of the stannous-containing sodium fluoride dentifrice relative to the negative control dentifrice.