IADR Abstract Archives
Clinical Efficacy of Four Experimental Toothpastes on Gloss and Smoothness
Objectives: To evaluate the effects of four experimental toothpastes with a novel alumina abrasive system and sodium tripolyphosphate (STP) on tooth gloss and smoothness compared to standard toothpaste after one and four weeks of twice daily use.
Methods:
This was a single centre, single (examiner) blind, randomised, five-group parallel study in healthy volunteers. 291 subjects were evaluated for tooth gloss (Sturzenberger's Gloss Index) and smoothness (hygienist tactile, clinical evaluation of smoothness) at Baseline, Week 1 and Week 4.
At baseline subjects were randomised to one of five toothpaste treatments (1.5% w/w Alumina and 7.5% w/w STP or 5% w/w STP, 1% w/w Alumina and 7.5% w/w STP or 5% w/w STP, and Aquafresh Advanced), after which subjects received a dental prophylaxis.
Subjects brushed twice daily at home with their allocated treatment for 4 weeks.
Results:
Table: Summary of change from baseline in Gloss and Smoothness (ITT population)
Variable | Week | 1.5% Alumina and 7.5% STP | 1.5% Alumina and 5% STP | 1% Alumina and 7.5% STP | 1% Alumina and 5% STP | Aquafresh Advanced |
|
| Adjusted Mean (SE) (p-value) | Adjusted Mean (SE) (p-value) | Adjusted Mean (SE) (p-value) | Adjusted Mean (SE) (p-value) | Adjusted Mean (SE) (p-value) |
Gloss | 4 | 0.77(0.073) <0.0001 | 0.82(0.071) <0.0001 | 0.81(0.071) <0.0001 | 0.69(0.073) <0.0001 | 0.29(0.072) <0.0001 |
Smoothness | 4 | -0.26(0.045) <0.0001 | -0.29(0.045) <0.0001 | -0.31(0.044) <0.0001 | -0.28(0.047) <0.0001 | -0.14(0.044) 0.0015 |
All the experimental formulations produced statistically significantly greater changes to gloss and smoothness as compared to baseline and to Aquafresh Advanced at both Weeks 1 and 4 ( p <0.05). All test products were well tolerated.
Conclusion: All experimental formulations demonstrated better efficacy on gloss and smoothness as compared to a standard silica toothpaste.