Effects of Chlorhexidine Listerine and Persica on alveolar bone healing

Objectives: The aim of this randomised controlled trial was to investigate the effects of Persica, Listerine and Chlorhexidine on alveolar bone healing following tooth extraction in rats. Methods: 27 Wistar rats were randomly allocated to three study groups; Chlorhexidine 0.2%, Persica and Listerine. Rats were mouthrinsed for 14 days. On day 8, the mandibular right first molars of all rats were extracted. On day 21, rats were euthanized and histological slides of their extraction sockets were prepared. The amount of new bone formation and the number of inflammatory cells in the extraction socket for each rat were recorded. Data were analysed using linear regression and Mann Whitney tests. Results: The mean new bone formation was significantly higher in the Persica group than in the Chlorhexine group and the Listerine group. There was no significant difference between Chlorhexidine and Listerine groups in terms of inflammatory cell count. There was no significant difference between three intervention groups in terms of inflammatory cell count. There was a significant association between new bone formation and inflammatory cell count in the entire sample. Conclusions: In conclusion, Persica was more likely to enhance new bone formation in rats, as compared with Chlorhexidine and Listerine. Chlorhexidine and Listerine were not significantly different in enhancing new bone formation. This may suggest that Persica is more effective than Chlorhexidine and Listering in healing extraction wound socket. However, inflammatory cell count was not significantly different between Chlorhexidine, Listerine and Persica. Further studies are required to further investigate the effects of different mouthrinses on extraction wound healing in the mouth.