Anti-Gingivitis Efficacy of a Stannous Containing Sodium Fluoride Toothpaste

Objective: This study was to evaluate the efficacy of a stannous containing fluoride toothpaste in the control of plaque and gingivitis as compared to a commercially available MFP dentifrice. Methods: One hundred subjects who met inclusion criteria were enrolled into the controlled, randomized, double-blind and parallel 12-week study. Subjects were stratified into two treatment groups which were balanced for age, sex, baseline Turesky modification of Quigley Hein plaque index (TMQHPI), and baseline Loe-Silness Gingival Index scores. Subjects were randomly assigned to one of two treatment group and instructed to brush their teeth twice daily (morning and evening) for one minute with their assigned dentifrice, and a soft-bristled toothbrush. Clinical examination was conducted at week 6 and week 12. Analysis of variance (ANOVA) was used to compare the plaque index and Gingivitis index data. All comparisons were two-sided with a level of significance of a=0.05. Results: Eighty six subjects completed the entire 12 weeks procedure. After 12 weeks product usage, the stannous-containing sodium fluoride dentifrice demonstrated statistically significant reduction(13.77%) in gingivitis as compared to the control toothpaste(P<0.05), and statistically significant reduction(13.95%) in plaque reduction relative to negative control (p<0.05). Conclusions: The study demonstrated the anti-plaque and anti-gingivitis efficacy of the stannous-containing sodium fluoride dentifrice.