De-sensitizing effect of a Stannous containing sodium fluoride novel dentifrice

Objective: to evaluate the de-sensitizing effect of a stannous containing sodium fluoride toothpaste relative to a negative control. Methods: Eighty subjects who met inclusion criteria were enrolled into a controlled and randomized, double-blind parallel 8-week study. Test products included a stannous-containing sodium fluoride (1450ppm) dentifrice and a marketed MFP containing dentifrice (Colgate® Cavity protection)At Baseline, efficacy assessments including tactile ( 2000A Yeaple, Pittsford, NY) and thermal (Schiff air index) were taken. Subjects were randomly assigned to one of two treatment used the product twice daily for 8 weeks and one minute each time. Clinical examination was again conducted at week 4 and week 8. Statistical comparisons were two-sided with a significance level of 0.05 Results: After 8 weeks product usage, the stannous-containing sodium fluoride dentifrice provided statistically significantly better de-sensitizing efficacy relative to the negative control ( p<0.05) on tactile measurement with average of 23.1 and 17.1 respectively, and significantly better de-sensitizing efficacy relative to negative control (p<0.05) on thermal measurement with average of 1.67 and 1.96 respectively.. Conclusions: The study demonstrated the de-sensitizing efficacy of the stannous-containing sodium fluoride dentifrice.