De-sensitizing effect of a Stannous containing sodium fluoride toothpaste

Objective: to evaluate the de-sensitizing effect of a stannous containing sodium fluoride toothpaste relative to a negative control. Methods: Eighty subjects who met inclusion criteria were enrolled into a controlled and randomized, double-blind parallel 8-week study. Test products included a stannous-containing sodium fluoride (1450ppm) dentifrice and a negative control dentifrice (Colgate® Cavity protection-Super Strong). At Baseline, Efficacy assessments including tactile ( 2000A Yeaple, Pittsford, NY) and thermal (Schiff air index) were taken. Subjects were randomly assigned to one of two treatment used the product twice daily for 8 weeks and two minutes each time. Post treatment clinical examination was conducted at week 4 and week 8. Analysis of covariance was used to analyze data. All comparisons were two-sided with a significance level of 0.05. Results: After 8 weeks product usage, the stannous-containing sodium fluoride dentifrice provided statistically significantly better (233%) de-sensitizing efficacy relative to the negative control ( p<0.001) on tactile measurement, and significantly better(64%) de-sensitizing efficacy relative to negative control (p<0.001) on thermal measurement. Conclusions: The study demonstrated the de-sensitivity efficacy of the stannous-containing sodium fluoride dentifrice.