Materials and Methods: The Poly (amino amine) dendrons were synthesized and further modified with aspartic acid on the periphery and an aliphatic chain at the focal point (Sa-BM2-Asp). Sa-BM2-Asp was dissolved in dimethyl sulfoxide (DMSO) at the concentration of 10-3mol 20ìL and then dropped into the aqueous solution with calcium nitrate and diammonium hydrogen phosphate. The aggregation of Sa-BM2-Asp was confirmed by transmission electron microscopy (TEM), and crystals of AP developed with the assemblies from Sa-BM2-Asp as the template. The features of the obtained composite were determined by XRD, FT-IR, HRTEM and SEM.
Results: The aggregates of Sa-BM2-Asp were observed by TEM with the diameter around 15-35nm. FT-IR measurement was performed to characterize the structure of the deposition that was the crystals of AP. Moreover, the crystals of AP showed fiber-like morphology. XRD result provided that the growth of the crystals was along with the direction of (002).
Conclusion: The newly synthesized amphiphilic dendritic molecule could self-assemble in aqueous solution. It would act as a template for the mineralization, leading to the orientation development of apatite.