Instant effectiveness comparing Colgate Sensitive Pro-Relief and Sensodyne Rapid Relief

METHODS: The study was randomized and double-blind with a parallel-group design. Subjects with two hypersensitivity teeth (tactile score: 10-50 g; air blast score: 2-3), participated in the study. Study Phase I consisted of a single self-application of a pea-size amount of the assigned toothpaste directly onto the hypersensitive surface of the teeth followed with one-minute massaging. The Phase II consisted of twice-daily at-home brushing with the toothpaste for 7 days.

RESULTS: A total of 150 subjects (50/group) completed the study. At the baseline, no statistical differences in the tactile and air blast scores were indicated. After direct fingertip application, the positive control group achieved a significantly more instant hypersensitivity reduction than the test and negative control groups in tactile (91.0% and 80.5%, respectively) and air blast scores (44.8% and 41.4%, respectively). After brushing for 7 days, the positive control group maintained the significantly more hypersensitivity reduction than the test and negative control groups in tactile (43.9% and 32.1%, respectively) and air blast scores (54.1% and 50.4%, respectively). There were no statistical differences in tactile and air blast scores between the test and negative control groups either instantly or after 7 days.

CONCLUSION: The study results support the following conclusions: (1) Colgate Sensitive Pro-Relief toothpaste provides a significantly more reduction in dentin hypersensitivity than Sensodyne Rapid Relief and Crest fluoride toothpastes, instantly after a fingertip self-application and after 7 days of brushing; and (2) there are no significant differences between Sensodyne Rapid Relief and Crest fluoride toothpastes on tactile and air blast scores.