IADR Abstract Archives

A Novel System of Measuring the Outcome in Clinical Trials

Objectives: Aim of the study was to develop surrogate parameter for a broad application in therapy studies. The first application is based on a randomized clinical trial investigating materials for temporary restorations using Protemp®3 Garant®, Luxatemp® und Dentalon plus®.

Methods: 121 patients were included in the study. Different handling characteristics were examined during the manufacturing of the temporary restorations. Periodontal findings of every treated tooth and the adjacent teeth were collected and differences between pretreatment and post-treatment scores were analyzed. For the evaluation of the clinical performance an over-all parameter (Clinical Success Parameter, CSP) and a parameter assessing mechanical properties and patient's satisfaction (Clinical Success, CS) were developed. The clinical assessment was based on a system of modified CDA criteria. Two positive ratings (clinically good, clinically sufficient) and one negative rating (not acceptable) were created.

Results: Temporary restorations revealed a high level of clinical reliability. The median showed no alteration of the gingival health and no increased plaque adherence. CS was rated better for the Composites Protemp 3 and Luxatemp compared to the PMMA-product Dentalon plus. No differences were found concerning the over-all parameter CSP.

Conclusion: The surrogate parameter developed during the investigation seem to be adequate in order to evaluate clinical relevant differences between different groups.

The clinical trial was funded by 3M ESPE.


Division: IADR/AADR/CADR General Session
Meeting: 2011 IADR/AADR/CADR General Session (San Diego, California)
Location: San Diego, California
Year: 2011
Final Presentation ID: 1692
Abstract Category|Abstract Category(s): Dental Materials 4: Clinical Trials
Authors
  • Just, Benjamin A.  ( Ulm University Hospital - Center of Dentistry, Ulm, N/A, Germany )
  • Quaas, S  ( Ulm University Hospital - Center of Dentistry, Ulm, N/A, Germany )
  • Luthardt, Rg  ( Ulm University Hospital - Center of Dentistry, Ulm, N/A, Germany )
  • SESSION INFORMATION
    Oral Session
    Clinical Studies
    03/18/2011