Objective: Infection control/safety programs are closely linked in the dental setting. The purpose of this investigation was to determine the effectiveness of the programs of infection control and safety at Loma Linda University School of Dentistry. Methods: A new Infection Control/Safety Manager was appointed in 2006 to implement educational and monitoring programs in 2007. New faculty, staff and students must attend a 3-hr program, while the second-year dental students are required to take a 1-hr review course in infection control and safety before they are permitted to treat patients in the clinic. In addition, all faculty and staff are mandated to take an annual online testing of Basic Learning Units for Employees (BLUE). The 2007-2009 annual compliance data were retrospectively compiled and compared to 2006 outcomes. The data sets included annual numbers of infection control/OSHA citations, incidences of body fluid exposure and swallowed/aspirated foreign objects. The data were reviewed and analyzed, when applicable, using the Chi-square or Fisher Exact Test. Results: The compliance rate for the BLUE testing increased annually, from 59% for 2006 to 62%, 79% and 79% for years 2007, 2008 and 2009, respectively; the 2009 compliance rate was for 9 months only. While the data were not significantly different, a trend for improved compliance is evident. The annual incidence for numbers of infection control/OSHA citations and incidences of body fluid exposure and swallowed/aspirated foreign objects has remained at <0.00065%. Conclusion: Monitoring compliance by faculty, students and staff members is challenging. With collective efforts from school administration and competent management, the newly implemented infection control/safety program was found to improve compliance.