In-vitro-Fluoride-Bioavailability and Cleaning-Efficacy of a Triclosan/Copolymer/Silicon Dioxide/NaF Dentifrice

Objective: Measure the in-vitro fluoride bioavailability and cleaning efficacy of a new anti-sensitivity dentifrice containing triclosan/copolymer/silicon-dioxide/NaF with specially-designed silica to occlude tubules. Methods: The fluoride bioavailability evaluations were performed by fluoride uptake as per FDA Method #43 and enamel solubility reduction as per FDA Method # 36. The measurement of cleaning efficacy was evaluated via pellicle stain removal activity in the Pellicle Cleaning Ratio Test (PCR). The evaluations for fluoride bioavailability were performed on the new anti-sensitivity dentifrice containing triclosan/copolymer/silicon-dioxide/NaF (A), USP NaF-Silica-Reference Control (B) and a Silica Based Placebo (C). The measurement of cleaning efficacy was performed on the new anti-sensitivity dentifrice containing triclosan/copolymer/silicon-dioxide/NaF (A), Silica Based NaF Whitening Dentifrice (D) and Silica Based NaF Non Whitening Dentifrice (E). Results: Fluoride uptake results (ppmF/gram) were (A) = 56±4.7, (B) = 56±5.2 and (C) = 2±3.2, ANOVA analysis (LSD, p<0.05) confirmed A=B>C. Enamel solubility results were (A) = 35±4.6, (B) = 36±4.3 and (C) = 6±2.6, ANOVA analysis (LSD, p<0.05) confirmed A=B>C. The PCR scores were (A) 93.0 ±4.13, (D) 92.6 ±2.76 and (E) 70.3±4.74, ANOVA analysis (LSD, p<0.05) confirmed A=D>E. Conclusions: The fluoride bioavailability results indicate that the new anti-sensitivity dentifrice containing triclosan/copolymer/silicon-dioxide/NaF was not significantly different than the positive control (p<0.05) and was significantly more effective than the placebo dentifrice (p<0.05). The PCR results demonstrate the cleaning efficacy of the new anti-sensitivity dentifrice containing triclosan/copolymer/silicon-dioxide/NaF was equal to a Silica Based NaF Whitening Dentifrice (p<0.05) and significantly more effective than a Silica Based NaF Non-Whitening Dentifrice (p<0.05).