IADR Abstract Archives

Reoxygenation After Nitrous Oxide/ Oxygen Sedation: Science or Dogma?

INTRODUCTION: The protocols for administration of nitrous oxide sedation vary greatly between countries and available equipment. In particular, differences concern the systematic administration of oxygen at the end of the session. This study aims to evaluate the benefit of reoxygenation following conscious sedation using a 50% nitrous oxide/ 50% oxygen premix.

MATERIAL AND METHOD:This prospective randomized, comparative and double blind, phase III study compared variations in blood oxygen concentration between patients given either oxygen or air in the recovery period following nitrous oxide conscious sedation. After completion of dental treatment under 50% nitrous oxide in oxygen (Kalinox® 170 bar, Air Liquide Santé International), patients were randomly selected to receive either medicinal oxygen or medical air for 5 minutes during recovery (oxygen group: 65 patients, mean age 17.17±1.12 years; air group: 62 patients, mean age 17.23±1.34 years). Both gas were conditioned in blinded cylinders and were regulated at a flow rate of 4 to 15 litres/minute. SpO2 was recorded before, during and after treatment and recovery.

RESULTS: Mean SpO2 values did not differ between groups before induction: 98.84% ±0.14 in the oxygen group and 98.25% ±0.18 in the air group. During Kalinox® administration, SpO2 increased slightly in both groups (air group= +0.66% ±0.1; oxygen group= +0.24% ±0.19). During recovery, SpO2 increased slightly in the group receiving supplemental oxygen (+0.06% ±0.11) whilst it decreased in the group receiving air (-0.51% ±0.15) (p=0.0002, GLM procedure). Finally, during the post recovery period in ambient air, mean SpO2 decreased by -0.13% ±0.08 in the oxygen group and by 0.03% ±0.11 in the air group (not significant p=0.27). No differences were clinically significant.

CONCLUSION: Systematic reoxygenation after administration of 50% N2O/ 50% O2 premix for sedation in dentistry is unnecessary for ASA 1 or ASA 2 patients.

This study was sponsored by Air Liquide Santé International


IADR/PER General Session
2010 IADR/PER General Session (Barcelona, Spain)
Barcelona, Spain
2010
297
Dental Anesthesiology Research
  • Collado, Valerie  ( CHU of Clermont Ferrand, Clermont-Ferrand, N/A, France )
  • Faulks, Denise  ( CHU of Clermont Ferrand, Clermont-Ferrand, N/A, France )
  • Nicolas, Emmanuel  ( Université d'Auvergne, Clermont1, Clermont-Ferrand, N/A, France )
  • Onody, Peter  ( Air Liquide Santé International, Gentilly, N/A, France )
  • Hennequin, Martine  ( Université d'Auvergne, Clermont1, Clermont-Ferrand, N/A, France )
    • Oral Session
    Dental Anesthesiology Research I
    07/14/2010