IADR Abstract Archives

Porous Titanium Granules in Furcation Defects- An Animal Experimental Study

Objectives: The aim of this experimental investigation was to evaluate osseous regenerative properties of porous titanium granules (PTG, Natix, Tigran AB, Malmö, Sweden) when used as a bone graft substitute in experimental, degree II furcation defects in mini-pig premolars. Potential side-effects like root resorption and inflammation were also studied. Methods: A split mouth animal experimental study was performed in 11 female Gottingen mini pigs (Sus Scrofa, Mollegard Denmark). Buccal degree II furcation defects were surgically created in maxillary premolar teeth P2, P3 and P4 and randomized into treatment with either PTG , Bovine-Hydroxyapatite (B-HA, Bio-Oss, Geistlich, Wolhausen, Switzerland) or left empty (sham). After 6 weeks of healing the pigs were examined clinically, euthanized and jaw segment containing teeth with defects excised en bloc and analyzed by histology and micro CT. Results: The PTG appeared to integrate well into the alveolar bone. The morphology of the new bone appeared normal and had a distribution roughly matching the distribution of the granules. The micro CT results demonstrated significantly more regenerated bone in furcation defects grafted with PTG compared to B-HA and sham defects. The histological analysis demonstrated significantly better vertical osseous regeneration for PTG treated defects compared to B-HA treated defects but not to sham treated defects. Sporadic examples of regeneration of periodontal ligament and a few incidences of root resorption were seen but the differences between treatment groups were not significant. Conclusion: Within the limitations of this animal experimental study it was shown that degree II furcation defects in minipigs grafted with PTG demonstrated significantly better osseous regeneration compared B-HA grafted defects. No significant signs of adverse events were seen in any of the treatment groups.
IADR/PER General Session
2010 IADR/PER General Session (Barcelona, Spain)
Barcelona, Spain
2010
3862
IADR/Unilever Hatton Awards
  • Wohlfahrt, Johan Caspar  ( University of Oslo, Oslo, N/A, Norway )
  • Rønold, Hans Jacob  ( University of Oslo, Oslo, N/A, Norway )
  • Aass, Anne Merete  ( University of Oslo, Oslo, N/A, Norway )
  • Heijl, Lars  ( The Sahlgrenska Academy at Göteborg University, Göteborg, N/A, Sweden )
  • Lyngstadaas, Ståle Petter  ( University of Oslo, Oslo, N/A, Norway )
  • Poster Session
    IADR/Unilever Hatton Awards - Senior Category: Basic Science
    07/17/2010