Methods: Test group (FAIL) consisted of 32 patients (mean age=51 years) with one and more eliminated implants and control group (SUCC) of 25 patients (mean age=49,5 years) with one or more successfully osseointegrated dental implants over the 5 years period. The levels of interleukin (IL)-1beta, IL-4, IL-6 were assessed in the lymphocytes cultures without stimulation and by stimulation with titanium (Ti) antigen. The levels of albumin and IgA were also assessed in the saliva.
Results: The levels of IL-1beta were significantly increased in the both groups of patients after the lymphocyte culture stimulation with Ti antigen against the lymphocyte culture without stimulation. The levels of IL-4 were not significantly different. The levels of IL-6 were significantly increased in the SUCC group after the stimulation with Ti antigen. Significant increase of IgA was found in saliva in the FAIL group. No difference was found in saliva albumin levels between FAIL and SUCC groups of patients.
Conclusion: We observed that the levels of IL-1beta and IL-6 are affected by stimulation with Ti antigen. Increased levels of IL-6 were found only in the SUCC group indicating the role of this interleukin in the healing process during the dental implants therapy. Increased salivary levels of IgA in FAIL group may by sign of started immunopathological reaction.
Acknowledgement: The study was supported by the IGA grant of the Czech Ministry of Health no NS 10577-3.